Protein Domain : IPR031072

Type:  Family Name:  Syntrophin-1
Description:  Syntrophin-1 (stn-1) from the nematode Caenorhabditis elegans encodes a syntrophin with homology to vertebrate alpha and beta-syntrophins. Stn-1 is expressed in neurons and in muscles and its role is linked to dystrophin function []. It is part of the C. elegans dystrophin protein complex (DPC) required for maintaining neural integrity [, ]. Syntrophin-1 from Drosophila is required for locomotion and regulation of synaptic morphology [].Syntrophins are a family of PDZ domain-containing adaptor proteins required for receptor localisation. They are intracellular membrane-associated proteins that interact with both ion channels and signalling proteins. They appear to be important for linking ion channels to intracellular signalling pathways. Syntrophins are concentrated at postsynaptic sites at the neuromuscular junction and may be involved in clustering acetylcholine receptors. In muscle and non-muscle tissues, syntrophin is associated with dystrophin, utrophin, and two homologues of the dystrophin carboxy-terminal region []. Short Name:  Syntrophin-1

0 Child Features

0 Contains

1 Cross References

Identifier
PTHR10554:SF12

0 Found In

3 GO Annotations

GO Term Gene Name
GO:0005198 IPR031072
GO:0050808 IPR031072
GO:0016010 IPR031072

3 Ontology Annotations

GO Term Gene Name
GO:0005198 IPR031072
GO:0050808 IPR031072
GO:0016010 IPR031072

1 Parent Features

DB identifier Type Name
IPR015482 Family Syntrophin

0 Proteins

5 Publications

First Author Title Year Journal Volume Pages PubMed ID
            7691103
            14499607
            12234669
            21242290
            20632467