Protein Domain : IPR001067

Type:  Family Name:  Nuclear translocator
Description:  The Ah (dioxin) receptor nuclear translocator protein (Arnt) belongs to the basic helix-loop-helix (bHLH) family of transcription factors and is required forAh receptor function. The Ah receptor binds, and mediates the carcinogenic effects of a variety of environmental pollutants, including 2,3,7,8-tetrachlorodibenzo-p-dioxin and polycyclic aromatic hydrocarbons. Arnt is a structural component of theXRE-binding form of the Ah receptor. These proteins are class VII members of the basic helix-loop-helix (bHLH) family. The bHLH domain may be responsible for interacting with both the XRE and the ligand-binding subunit [, ].The activated Ah receptor and Arnt protein bind DNA as a heterodimer. Both proteins contain PAS homology regions, which in Drosophila PER and SIMproteins function as dimerisation domains []. Short Name:  Nuc_translocat
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0 Child Features

2 Contains

DB identifier Type Name
IPR011598 Domain Myc-type, basic helix-loop-helix (bHLH) domain
IPR013767 Domain PAS fold

1 Cross References

Identifier
PR00785

0 Found In

5 GO Annotations

GO Term Gene Name
GO:0003700 IPR001067
GO:0006355 IPR001067
GO:0005634 IPR001067
GO:0005667 IPR001067
GO:0005737 IPR001067

5 Ontology Annotations

GO Term Gene Name
GO:0003700 IPR001067
GO:0006355 IPR001067
GO:0005634 IPR001067
GO:0005667 IPR001067
GO:0005737 IPR001067

0 Parent Features

0 Proteins

2 Publications

First Author Title Year Journal Volume Pages PubMed ID
            8065341
            1317062