3 Ontology Annotations
| GO Term | Gene Name |
|---|---|
| GO:0016780 | IPR003542 |
| GO:0009239 | IPR003542 |
| GO:0009366 | IPR003542 |
| Type: | Family | Name: | Enterobactin synthetase-like, component D |
| Description: | Iron is essential for growth in both bacteria and mammals. Controlling the amount of free iron in solution is often used as a tactic by hosts to limitinvasion of pathogenic microbes; binding iron tightly within protein molecules can accomplish this. Such iron-protein complexes include haem in blood, lactoferrin in tears/saliva and transferrin in blood plasma. Somebacteria express surface receptors to capture eukaryotic iron-binding compounds, while others have evolved siderophores to scavenge iron fromiron-binding host proteins [].The absence of free iron molecules in the surrounding environment triggers transcription of gene clusters that encode both siderophore-synthesis enzymes, and receptors that recognise iron-bound siderophores []. Classicexamples are the enterobactin/enterochelin clusters found in Escherichia coliand Salmonella, although similar moieties in other pathogens have been identified. The enzymic machinery that produces vibrionectin in Vibrio choleraeis such a homologue [].EntD forms part of the enterobactin-synthetase enzyme complex. It is involved in the final stage of enterobactin biosynthesis, converting2,3-dihydroxybenzoic acid (DHBA) and L-serine to enterobactin. Deletion studies involving EntD- mutants have shown that it is essential forvirulence [].This entry also identifies some 4'-phosphopantetheinyl transferase proteins. | Short Name: | Enbac_synth_compD-like |
| GO Term | Gene Name |
|---|---|
| GO:0016780 | IPR003542 |
| GO:0009239 | IPR003542 |
| GO:0009366 | IPR003542 |
