Protein Domain : IPR018295

Type:  Conserved_site Name:  FLAP/GST2/LTC4S, conserved site
Description:  These are proteins of 150 to 160 residues that contain three transmembrane segments. As a signature for these proteins a conserved region between the first and second transmembrane domains has been used. This entry contains the following mammalian proteins, which are evolutionary related []: Leukotriene C4 synthase () (gene LTC4S), an enzyme that catalyzes the production of LTC4 from LTA4. Microsomal glutathione S-transferase II () (GST-II) (gene GST2), an enzyme that can also produces LTC4 fron LTA4. 5-lipoxygenase activating protein (gene FLAP), a protein that seems to be required for the activation of 5-lipoxygenase. Short Name:  FLAP/GST2/LTC4S_CS
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0 Child Features

0 Contains

1 Cross References

Identifier
PS01297

2 Found Ins

DB identifier Type Name
IPR001129 Family Membrane-associated, eicosanoid/glutathione metabolism (MAPEG) protein
IPR001446 Family 5-lipoxygenase-activating protein

3 GO Annotations

GO Term Gene Name
GO:0008047 IPR018295
GO:0006691 IPR018295
GO:0016021 IPR018295

3 Ontology Annotations

GO Term Gene Name
GO:0008047 IPR018295
GO:0006691 IPR018295
GO:0016021 IPR018295

0 Parent Features

0 Proteins

1 Publications

First Author Title Year Journal Volume Pages PubMed ID
            8703034