Type: | Domain | Name: | Clostridium neurotoxin, receptor-binding C-terminal |
Description: | The Clostridium neurotoxin family is composed of tetanus neurotoxins and seven serotypes of botulinum neurotoxin. The structure of the botulinum neurotoxin reveals a four domain protein. The N-terminal catalytic domain (), the central translocation domains and two receptor-binding domains []. This domain is the C-terminal receptor-binding domain, which adopts a modified beta-trefoil fold with a six stranded beta-barrel and a beta-hairpin triplet capping the domain []. The first step in the intoxication process is a binding event between this domain and the pre-synaptic nerve ending []. | Short Name: | Toxin_rcpt-bd_C |