Protein Domain : IPR031234

Type:  Family Name:  Latrophilin-1
Description:  Latrophilins are a family of secretin-like GPCRs that can be subdivided into 3 subtypes: Latrophilin-1 (LPH1), -2 (LPH2), and -3 (LPH3). LPH1 is a brain-specific calcium independent receptor of alpha-latrotoxin (LTX), an neurotoxin present in black widow spider venom which triggers massive exocytosis from presynaptic nerve terminals [, ].Two endogenous ligands for latrophilins have been described, teneurin-2 [] and FLRT3 []. LPH1 has been shown to bind Lasso (a splice variant of teneurin-2). LPH1 and Lasso interact across intercellular and synaptic junctions, suggesting an involved in synaptic functions []. Latrophilins are potential synaptic cell-adhesion molecules that interact trans-synaptically with teneurins and FLRTs []. Short Name:  Latrophilin-1
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0 Child Features

0 Contains

1 Cross References

Identifier
PTHR12011:SF62

0 Found In

6 GO Annotations

GO Term Gene Name
GO:0004930 IPR031234
GO:0016524 IPR031234
GO:0007157 IPR031234
GO:0016079 IPR031234
GO:0090129 IPR031234
GO:0045202 IPR031234

6 Ontology Annotations

GO Term Gene Name
GO:0004930 IPR031234
GO:0016524 IPR031234
GO:0007157 IPR031234
GO:0016079 IPR031234
GO:0090129 IPR031234
GO:0045202 IPR031234

1 Parent Features

DB identifier Type Name
IPR003924 Family GPCR, family 2, latrophilin

0 Proteins

5 Publications

First Author Title Year Journal Volume Pages PubMed ID
            21724987
            11520923
            22405201
            24273166
            9208860