3 Ontology Annotations
| GO Term | Gene Name |
|---|---|
| GO:0004616 | IPR006184 |
| GO:0006098 | IPR006184 |
| GO:0055114 | IPR006184 |
| Type: | Binding_site | Name: | 6-phosphogluconate-binding site |
| Description: | 6-Phosphogluconate dehydrogenase () (6PGD) is an oxidative carboxylase that catalyses the decarboxylating reduction of 6-phosphogluconate into ribulose 5-phosphate in the presence of NADP. This reaction is a component of the hexose mono-phosphate shunt and pentose phosphate pathways (PPP) [, ]. Prokaryotic and eukaryotic 6PGD are proteins of about 470 amino acids whose sequences are highly conserved []. The protein is a homodimer in which the monomers act independently []: each contains a large, mainly alpha-helical domain and a smaller beta-alpha-beta domain, containing a mixed parallel and anti-parallel 6-stranded beta sheet []. NADP is bound in a cleft in the small domain, the substrate binding in an adjacent pocket []. This signature, found in the C-terminal all-alpha domain of 6-phosphogluconate dehydrogenase, contains the 6-phosphogluconate binding site. The NAD-binding domain is described in . | Short Name: | 6PGdom_BS |
| GO Term | Gene Name |
|---|---|
| GO:0004616 | IPR006184 |
| GO:0006098 | IPR006184 |
| GO:0055114 | IPR006184 |
