| Type: | Domain | Name: | Transcriptional regulator SgrR, N-terminal HTH domain |
| Description: | Small, non-coding RNA molecules play important regulatory roles in a variety of physiological processes in bacteria. This entry represents the N-terminal domain of the SgrR family of proteins which regulate the transcription of these sRNAs, in particular SgrS. This domain contains a helix-turn-helix motif characteristic of winged-helix DNA-binding transcriptional regulators. SgrS is a small RNA required for recovery from glucose-phosphate stress in bacteria []. In examining the regulation of SgrR expression it was found that SgrR negatively auto-regulates its own transcription in the presence and absence of stress, and thus SgrR coordinates the response to glucose-phosphate stress by binding specifically to sgrS promoter DNA []. | Short Name: | SgrR_HTH_N |
