Protein Domain : IPR001860

Type:  Family Name:  Glycoside hydrolase, family 34
Description:  O-Glycosyl hydrolases () are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. A classification system for glycosyl hydrolases, based on sequence similarity, has led to the definition of 85 different families [, ]. This classification is available on the CAZy (CArbohydrate-Active EnZymes) web site.Glycoside hydrolase family 34 comprises enzymes with only one known activity; sialidase or neuraminidase .Neuraminidases cleave the terminal sialic acid residues from carbohydrate chains in glycoproteins. Sialic acid is a negatively charged sugar associated with the protein and lipid portions of lipoproteins. In Influenza virus, neuraminidases prevent self-aggregation by removing the carbohydrate from the viral envelope thus facilitating the mobility of the virus to and from the site of infection. Antiviral agents that inhibit influenza viral neuraminidase activity are of major importance in the control of influenza []. Short Name:  Glyco_hydro_34
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0 Child Features

1 Contains

DB identifier Type Name
IPR011040 Domain Sialidases

1 Cross References

Identifier
PF00064

0 Found In

5 GO Annotations

GO Term Gene Name
GO:0004308 IPR001860
GO:0005975 IPR001860
GO:0016020 IPR001860
GO:0033644 IPR001860
GO:0055036 IPR001860

5 Ontology Annotations

GO Term Gene Name
GO:0004308 IPR001860
GO:0005975 IPR001860
GO:0016020 IPR001860
GO:0033644 IPR001860
GO:0055036 IPR001860

0 Parent Features

0 Proteins

3 Publications

First Author Title Year Journal Volume Pages PubMed ID
            7624375
            8535779
            10623375