| Type: | Conserved_site | Name: | Solute-binding family 1, conserved site |
| Description: | Bacterial high affinity transport systems are involved in active transport of solutes across the cytoplasmic membrane. Most of the bacterial ABC (ATP-binding cassette) importers are composed of one or two transmembrane permease proteins, one or two nucleotide-binding proteins and a highly specific periplasmic solute-binding protein. In Gram-negative bacteria the solute-binding proteins are dissolved in the periplasm, while in archaea and Gram-positive bacteria, their solute-binding proteins are membrane-anchored lipoproteins [, ]. On the basis of sequence similarities, the vast majority of these solute-binding proteins can be grouped [] into eight families or clusters, which generally correlate with the nature of the solute bound. This entry represents a conserved site found in the extracellular solute-binding protein family 1 members from Gram-positive bacteria, Gram-negative bacteria and archaea. Family 1 members include:Maltose/maltodextrin-binding proteins of Enterobacteriaceae (gene malE) [] and Streptococcus pneumoniae malXMultiple oligosaccharide binding protein of Streptococcus mutans (gene msmE)Escherichia coli glycerol-3-phosphate-binding proteinSerratia marcescens iron-binding protein (gene sfuA) and the homologous proteins (gene fbp) from Haemophilus influenzae and NeisseriaE. coli thiamine-binding protein (gene tbpA) | Short Name: | SBP_1_CS |
