| Type: | Family | Name: | Homeobox protein GBX-2 |
| Description: | Gbx-2 is a homeobox protein essential for normal development of the midbrain and the anterior hindbrain [, , ]. It functions as a transcriptional repressor to regulate the specification and morphogenesis of the mid-hindbrain junction in a dosage- and stage-dependent manner [].The homeobox domain (homeodomain) is a 60-residue motif first identified in a number of Drosophila homeotic and segmentation proteins, but now known to be well-conserved in many other animals, including vertebrates [, ]. Proteins containing homeobox domains are likely to play an important role in development - most are known to be sequence-specific DNA-binding transcription factors. The domain binds DNA through a helix-turn-helix (HTH) structure. | Short Name: | GBX-2 |
