Type: | Family | Name: | Peptidase S24, LexA-like |
Description: | This signature defines serine peptidases belong to MEROPS peptidase family S24 (LexA family, clan SF). They include:LexA, the repressor of genes in the cellular SOS response to DNA damageMucA and the related UmuD proteins, which are lesion-bypass DNA polymerases, induced in response to mitogenic DNA damageRumA a plasmid encoded homologue of UmuD []RuvA, which is a component of the RuvABC resolvasome that catalyses the resolution of Holliday junctions that arise during genetic recombination and DNA repair []The LexA, UmuD and MucD proteins interact with RecA, which activates self cleavage either derepressing transcription in the case of LexA [] or activating the lesion-bypass polymerase in the case of UmuD and MucA. UmuD'2, is the homodimeric component of DNA pol V, which is produced from UmuD by RecA-facilitated self-cleavage. The first 24 N-terminal residues of UmuD are removed; UmuD'2 is a DNA lesion bypass polymerase [, ]. MucA [, ], like UmuD, is a plasmid encoded a DNA polymerase (pol RI) which is converted into the active lesion-bypass polymerase by a self-cleavage reaction involving RecA [].This group of proteins also contains proteins classified as non-peptidase homologues as they either have been found experimentally to be without peptidase activity, or lack amino acid residues that are believed to be essential for catalytic activity. | Short Name: | Peptidase_S24_LexA |