GO Term : GO:1903303 negative regulation of pyruvate kinase activity GO

Namespace:  biological_process Obsolete:  false
description  Any process that stops, prevents or reduces the frequency, rate or extent of pyruvate kinase activity.

0 Cross References

0 Data Sets

1 Ontology

Name
GO

0 Ontology Annotations

146 Parents

Identifier Name Description
GO:0003824 catalytic activity Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic.
GO:0004743 pyruvate kinase activity Catalysis of the reaction: ATP + pyruvate = ADP + phosphoenolpyruvate.
GO:0006096 glycolytic process The chemical reactions and pathways resulting in the breakdown of a carbohydrate into pyruvate, with the concomitant production of a small amount of ATP and the reduction of NAD(P) to NAD(P)H. Glycolysis begins with the metabolism of a carbohydrate to generate products that can enter the pathway and ends with the production of pyruvate. Pyruvate may be converted to acetyl-coenzyme A, ethanol, lactate, or other small molecules.
GO:0046034 ATP metabolic process The chemical reactions and pathways involving ATP, adenosine triphosphate, a universally important coenzyme and enzyme regulator.
GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule.
GO:0016310 phosphorylation The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide.
GO:0016772 transferase activity, transferring phosphorus-containing groups Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor).
GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation.
GO:0006796 phosphate-containing compound metabolic process The chemical reactions and pathways involving the phosphate group, the anion or salt of any phosphoric acid.
GO:0019752 carboxylic acid metabolic process The chemical reactions and pathways involving carboxylic acids, any organic acid containing one or more carboxyl (COOH) groups or anions (COO-).
GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances.
GO:0006165 nucleoside diphosphate phosphorylation The process of introducing a phosphate group into a nucleoside diphosphate to produce a nucleoside triphosphate.
GO:0016773 phosphotransferase activity, alcohol group as acceptor Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor).
GO:0006807 nitrogen compound metabolic process The chemical reactions and pathways involving organic or inorganic compounds that contain nitrogen, including (but not limited to) nitrogen fixation, nitrification, denitrification, assimilatory/dissimilatory nitrate reduction and the interconversion of nitrogenous organic matter and ammonium.
GO:0006139 nucleobase-containing compound metabolic process Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids.
GO:0016740 transferase activity Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2.
GO:0071704 organic substance metabolic process The chemical reactions and pathways involving an organic substance, any molecular entity containing carbon.
GO:0009116 nucleoside metabolic process The chemical reactions and pathways involving a nucleoside, a nucleobase linked to either beta-D-ribofuranose (a ribonucleoside) or 2-deoxy-beta-D-ribofuranose, (a deoxyribonucleoside), e.g. adenosine, guanosine, inosine, cytidine, uridine and deoxyadenosine, deoxyguanosine, deoxycytidine and thymidine (= deoxythymidine).
GO:0006082 organic acid metabolic process The chemical reactions and pathways involving organic acids, any acidic compound containing carbon in covalent linkage.
GO:0006090 pyruvate metabolic process The chemical reactions and pathways involving pyruvate, 2-oxopropanoate.
GO:0044238 primary metabolic process The chemical reactions and pathways involving those compounds which are formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism.
GO:0009117 nucleotide metabolic process The chemical reactions and pathways involving a nucleotide, a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety; may be mono-, di- or triphosphate; this definition includes cyclic nucleotides (nucleoside cyclic phosphates).
GO:0006725 cellular aromatic compound metabolic process The chemical reactions and pathways involving aromatic compounds, any organic compound characterized by one or more planar rings, each of which contains conjugated double bonds and delocalized pi electrons, as carried out by individual cells.
GO:0019439 aromatic compound catabolic process The chemical reactions and pathways resulting in the breakdown of aromatic compounds, any substance containing an aromatic carbon ring.
GO:0050790 regulation of catalytic activity Any process that modulates the activity of an enzyme.
GO:0006163 purine nucleotide metabolic process The chemical reactions and pathways involving a purine nucleotide, a compound consisting of nucleoside (a purine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar.
GO:0006091 generation of precursor metabolites and energy The chemical reactions and pathways resulting in the formation of precursor metabolites, substances from which energy is derived, and any process involved in the liberation of energy from these substances.
GO:0043086 negative regulation of catalytic activity Any process that stops or reduces the activity of an enzyme.
GO:0045980 negative regulation of nucleotide metabolic process Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving nucleotides.
GO:0009166 nucleotide catabolic process The chemical reactions and pathways resulting in the breakdown of nucleotides, any nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety; may be mono-, di- or triphosphate; this definition includes cyclic-nucleotides (nucleoside cyclic phosphates).

236 Relations

Relationship
Parent Term . Identifier

Child Term . Identifier
is_a GO:0045820 GO:1903303
is_a GO:0051348 GO:1903303
is_a GO:0065007 GO:1903303
is_a GO:1903302 GO:1903303
negatively regulates GO:0004743 GO:1903303
negatively regulates GO:0004743 GO:1903303
negatively regulates GO:0009056 GO:1903303
is_a GO:0045912 GO:1903303
regulates GO:0051186 GO:1903303
regulates GO:0046031 GO:1903303
regulates GO:0032787 GO:1903303
negatively regulates GO:0072524 GO:1903303
negatively regulates GO:0072521 GO:1903303
regulates GO:0006807 GO:1903303
regulates GO:0044763 GO:1903303
regulates GO:0019693 GO:1903303
regulates GO:0004743 GO:1903303
regulates GO:0046700 GO:1903303
regulates GO:0043436 GO:1903303
regulates GO:1901564 GO:1903303
negatively regulates GO:0009167 GO:1903303
negatively regulates GO:0055086 GO:1903303
negatively regulates GO:0009166 GO:1903303
negatively regulates GO:0009161 GO:1903303
regulates GO:0019439 GO:1903303
regulates GO:0016052 GO:1903303
regulates GO:0046034 GO:1903303
negatively regulates GO:0044281 GO:1903303
regulates GO:0006139 GO:1903303
negatively regulates GO:0044724 GO:1903303

19 Synonyms

Name Type
down regulation of pyruvate kinase activity synonym
down-regulation of ATP:pyruvate 2-O-phosphotransferase activity synonym
down-regulation of phosphoenol transphosphorylase activity synonym
down-regulation of phosphoenolpyruvate kinase activity synonym
down-regulation of pyruvate kinase activity synonym
downregulation of ATP:pyruvate 2-O-phosphotransferase activity synonym
downregulation of phosphoenol transphosphorylase activity synonym
downregulation of phosphoenolpyruvate kinase activity synonym
downregulation of pyruvate kinase activity synonym
inhibition of ATP:pyruvate 2-O-phosphotransferase activity synonym
inhibition of phosphoenol transphosphorylase activity synonym
inhibition of phosphoenolpyruvate kinase activity synonym
inhibition of pyruvate kinase activity synonym
negative regulation of ATP:pyruvate 2-O-phosphotransferase activity synonym
negative regulation of phosphoenol transphosphorylase activity synonym
negative regulation of phosphoenolpyruvate kinase activity synonym
down regulation of ATP:pyruvate 2-O-phosphotransferase activity synonym
down regulation of phosphoenol transphosphorylase activity synonym
down regulation of phosphoenolpyruvate kinase activity synonym