Protein Domain : IPR003170

Type:  Family Name:  UDP-N-acetylenolpyruvoylglucosamine reductase
Description:  Members of this family are UDP-N-acetylenolpyruvoylglucosamine reductase enzymes, which are also called UDP-N-acetylmuramate dehydrogenases. This enzyme is responsible for the synthesis of UDP-N-acetylmuramic acid in bacterial cell wall biosynthesis and consequently provides an attractive target for the design of antibacterial agents. The crystal structure of UDP-N-acetylenolpyruvylglucosamine reductase in the presence of its substrate, enolpyruvyl-UDP-N-acetylglucosamine, has been solved to 2.7 A resolution. The structure reveals a novel flavin binding motif, shows a striking alignment of the flavin with the substrate, and suggests a catalytic mechanism for the reduction of this enol ether []. Short Name:  MurB
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0 Child Features

4 Contains

DB identifier Type Name
IPR006094 Domain FAD linked oxidase, N-terminal
IPR016169 Domain CO dehydrogenase flavoprotein-like, FAD-binding, subdomain 2
IPR011601 Domain UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal
IPR016167 Domain FAD-binding, type 2, subdomain 1

3 Cross Referencess

Identifier
PTHR21071
TIGR00179
MF_00037

0 Found In

2 GO Annotations

GO Term Gene Name
GO:0008762 IPR003170
GO:0055114 IPR003170

2 Ontology Annotations

GO Term Gene Name
GO:0008762 IPR003170
GO:0055114 IPR003170

0 Parent Features

85 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
81558 D8R0A1 PAC:15409051 Selaginella moellendorffii 332  
evm.model.supercontig_282.9 PAC:16416036 Carica papaya 275  
orange1.1g020076m A0A067F731 PAC:18094238 Citrus sinensis 331  
Ciclev10013657m V4UWA6 PAC:20796605 Citrus clementina 331  
Potri.017G115000.1 A0A2K1X6M0 PAC:26984542 Populus trichocarpa 171  
Gorai.001G202000.1 A0A0D2Q1S1 PAC:26823694 Gossypium raimondii 355  
11102 C1N9U3 PAC:27344002 Micromonas pusilla CCMP1545 249  
Thecc1EG019447t2 A0A061EHV5 PAC:27454223 Theobroma cacao 376  
Thecc1EG019447t1 A0A061EHV5 PAC:27454222 Theobroma cacao 376  
Thecc1EG019447t3 A0A061EHV5 PAC:27454224 Theobroma cacao 376  
Migut.L00318.1.p PAC:28934882 Mimulus guttatus 187  
Araha.11756s0294.1.p PAC:28856250 Arabidopsis halleri 346  
Prupe.8G147100.1.p M5W6B5 PAC:32083682 Prunus persica 341  
GSMUA_Achr7P11970_001 PAC:32301061 Musa acuminata 359  
Sphfalx0149s0022.1.p PAC:32615318 Sphagnum fallax 408  
Sphfalx0005s0059.1.p PAC:32623696 Sphagnum fallax 408  
Pp3c9_18240V3.1.p A9SKV4 PAC:32912541 Physcomitrium patens 382  
Pp3c9_18240V3.2.p A9SKV4 PAC:32912542 Physcomitrium patens 382  
Mapoly0081s0037.1.p A0A2R6WKB8 PAC:33018979 Marchantia polymorpha 361  
Aco001370.1 PAC:33053883 Ananas comosus 383  
Aqcoe3G035500.2.p PAC:33092605 Aquilegia coerulea 255  
Aqcoe3G035500.4.p PAC:33092606 Aquilegia coerulea 229  
Aqcoe3G035500.3.p PAC:33092604 Aquilegia coerulea 290  
Aqcoe3G035500.1.p PAC:33092602 Aquilegia coerulea 391  
Aqcoe3G035500.5.p PAC:33092603 Aquilegia coerulea 356  
Brdisv1pangenome1010679m.p PAC:33608130 Brachypodium distachyon Pangenome 311  
Brdisv1BdTR12c1040033m.p PAC:34405520 Brachypodium distachyon BdTR12c 322  
Brdisv1BdTR11A1048749m.p PAC:35688078 Brachypodium distachyon BdTR11a 311  
Brdisv1BdTR11A1041660m.p PAC:35696412 Brachypodium distachyon BdTR11a 294  
Solyc02g063180.2.1 PAC:36156915 Solanum lycopersicum 141  

1 Publications

First Author Title Year Journal Volume Pages PubMed ID
            7552726