| Type: | Family | Name: | Actin-related protein 2/3 complex subunit 5 |
| Description: | Arp2/3 binds to pre-existing actin filaments and nucleates new daughter filaments, and thus becomes incorporated into the dynamic actin network at the leading edge of motile cells and other actin-based protrusive structures []. In order to nucleate filaments, Arp2/3 must bind to a member of the N-WASp/SCAR family protein []. Arp2 and Arp3 are thought to be brought together after activation, forming an actin-like nucleus for actin monomers to bind and create a new actin filament. In the absence of an activating protein, Arp2/3 shows very little nucleation activity. Recent research has focused on the binding and hydrolysis of ATP by Arp2 and Arp3 [], and crystal structures of the Arp2/3 complex have been solved [].The human Arp2/3 complex consists of ARP2, ARP3, ARPC1B/p41-ARC, ARPC2/p34-ARC, ARPC3/p21-ARC, ARPC4/p20-ARC and ARPC5/p16-ARC. This family represents the ARPC5/p16-ARC subunit. | Short Name: | ARPC5 |
| DB identifier | Type | Name |
|---|---|---|
| IPR030075 | Family | Actin-related protein 2/3 complex subunit 5-like protein |
| GO Term | Gene Name |
|---|---|
| GO:0030833 | IPR006789 |
| GO:0034314 | IPR006789 |
| GO:0005885 | IPR006789 |
| GO:0015629 | IPR006789 |
| GO Term | Gene Name |
|---|---|
| GO:0030833 | IPR006789 |
| GO:0034314 | IPR006789 |
| GO:0005885 | IPR006789 |
| GO:0015629 | IPR006789 |
