| Type: | Domain | Name: | CXC domain |
| Description: | Polycomb group (Pc-G) proteins ensure the stable inheritance of expression patterns through cell division and regulate the control of cell proliferation.The Enhancer of zeste (E(z))-type of Pc-G proteins includes: Drosophila melanogaster Enhancer of zeste E(z).Mammalian ENX-1 and ENX-2.Arabidopsis thaliana CURLY LEAF (CLF), a transcriptional repressor of floral homeotic gene AGAMOUS.Arabidopsis thaliana CLF-like.Arabidopsis thaliana MEDEA (MEA), a suppressor of endosperm development.Arabidopsis thaliana EZA1.These proteins contain a SET domain at the C terminus. Unique to them is the presence of a CXC domain, an ~65-residue cys-rich regionpreceding the SET domain. The spacing of 17 cyteines is conserved. The CXC domain contains three units of C-X(6)-C-X(3)-C-X-C motif, although the most C-terminal unit is reverse-oriented. Because of its evolutionary conservation, the CXC domain is likely to be involved in an important function of E(z)-related proteins [, , ].The CXC domain shows some similarity to the CRC domain found in the tesmin/ TSO1 protein family []. | Short Name: | CXC_dom |
