3 Ontology Annotations
| GO Term | Gene Name |
|---|---|
| GO:0006351 | IPR010561 |
| GO:0007049 | IPR010561 |
| GO:0017053 | IPR010561 |
| Type: | Family | Name: | Protein LIN-9/Protein ALWAYS EARLY |
| Description: | This entry represents protein LIN-9/ALWAYS EARLY (LIN-9/ALY). LIN-9 from Caenorhabditis elegans is a homologue of the Drosophila always early (ALY) protein, which functions as a repressor of cell cycle regulated genes [, ].LIN-9 is a component of the evolutionary conserved DREAM (MuvB/DRM) complex, which represses transcription []. DREAM complex undergoes a cell cycle dependent switch of subunits. DREAM core binds to the E2F4 transcription factor and to the RBL2 (p130) in quiescent cells, while associates with the transcription factor B-MYB in the S-phase []. In humans, LIN-9 acts as a tumor suppressor and plays a role in the expression of genes required for the G1/S transition [, ]. In pluripotent embryonic stem cells (ESC), LIN-9 plays an important role for proliferation and genome stability by activating genes with important functions in mitosis and cytokinesis [].In Arabidopsis thaliana, ALY is expressed ubiquitously in vegetative and reproductive tissues []. | Short Name: | LIN-9/ALY1 |
| GO Term | Gene Name |
|---|---|
| GO:0006351 | IPR010561 |
| GO:0007049 | IPR010561 |
| GO:0017053 | IPR010561 |
