Protein Domain : IPR002695

Type:  Family Name:  AICARFT/IMPCHase bienzyme
Description:  This is a family of bifunctional enzymes catalysing the last two steps in de novopurine biosynthesis. The bifunctional enzyme is found in both prokaryotes and eukaryotes. The second last step is catalysed by 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase (AICARFT), this enzyme catalyses the formylation of AICAR with 10-formyl-tetrahydrofolate to yield FAICAR and tetrahydrofolate []. The last step is catalysed by IMP (Inosine monophosphate) cyclohydrolase (IMPCHase), cyclizing FAICAR (5-formylaminoimidazole-4-carboxamide ribonucleotide) to IMP []. Short Name:  AICARFT_IMPCHas
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0 Child Features

1 Contains

DB identifier Type Name
IPR011607 Domain Methylglyoxal synthase-like domain

6 Cross Referencess

Identifier
PTHR11692
PF01808
PIRSF000414
SM00798
TIGR00355
MF_00139

0 Found In

3 GO Annotations

GO Term Gene Name
GO:0003937 IPR002695
GO:0004643 IPR002695
GO:0006164 IPR002695

3 Ontology Annotations

GO Term Gene Name
GO:0003937 IPR002695
GO:0004643 IPR002695
GO:0006164 IPR002695

0 Parent Features

896 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
180496 D8SKB9 PAC:15413403 Selaginella moellendorffii 543  
evm.TU.contig_33226.1 PAC:16430229 Carica papaya 222  
evm.model.supercontig_30.140 PAC:16416934 Carica papaya 486  
29613.m000364 B9SXJ1 PAC:16803699 Ricinus communis 617  
Cucsa.134510.1 A0A0A0LRB7 PAC:16962804 Cucumis sativus 604  
Cucsa.134510.6 A0A0A0LRB7 PAC:16962809 Cucumis sativus 604  
Cucsa.134510.7 A0A0A0LRB7 PAC:16962810 Cucumis sativus 604  
Cucsa.134510.8 PAC:16962811 Cucumis sativus 417  
Cucsa.134510.2 A0A0A0LRB7 PAC:16962805 Cucumis sativus 604  
Cucsa.134510.3 A0A0A0LRB7 PAC:16962806 Cucumis sativus 604  
Cucsa.134510.4 A0A0A0LRB7 PAC:16962807 Cucumis sativus 604  
Cucsa.134510.5 A0A0A0LRB7 PAC:16962808 Cucumis sativus 604  
orange1.1g007549m A0A067GC93 PAC:18138495 Citrus sinensis 599  
orange1.1g009955m A0A067GCI9 PAC:18138496 Citrus sinensis 521  
orange1.1g007518m A0A067GPG0 PAC:18138494 Citrus sinensis 600  
AT2G35040.2 O64767 PAC:19639841 Arabidopsis thaliana 545  
AT2G35040.1 Q8RWT5 PAC:19639840 Arabidopsis thaliana 596  
Thhalv10016476m V4M762 PAC:20180386 Eutrema salsugineum 545  
Thhalv10016407m V4LNJ0 PAC:20180385 Eutrema salsugineum 600  
Ciclev10014669m V4W6X8 PAC:20818016 Citrus clementina 599  
Lus10014374 PAC:23143689 Linum usitatissimum 589  
Lus10023871 PAC:23160683 Linum usitatissimum 621  
Lus10013871 PAC:23159507 Linum usitatissimum 598  
Potri.010G011600.1 A0A2K1YM52 PAC:26979176 Populus trichocarpa 123  
Potri.016G107700.1 A0A2K1XDX2 PAC:27011917 Populus trichocarpa 80  
Potri.003G024400.1 A0A2K2B0G0 PAC:26998535 Populus trichocarpa 50  
Potri.010G114400.1 A0A2K1YSG5 PAC:26981364 Populus trichocarpa 598  
Potri.010G114400.2 PAC:26981365 Populus trichocarpa 558  
Potri.010G114400.3 PAC:26981366 Populus trichocarpa 332  
Potri.008G128300.1 A0A2K1ZG99 PAC:27038173 Populus trichocarpa 46  

1 Publications

First Author Title Year Journal Volume Pages PubMed ID
            9332377