| Type: | Family | Name: | ICln |
| Description: | ICln, known as methylosome subunit pICln or chloride conductance regulatory protein ICln, owes these different names to its function in multiple regulatory pathways [] as different as ion permeation, ribonucleoprotein biosynthesis and cytoskeletal organisation []. ICln can be identified both in the cytosol and in the cellular membrane, where it functions as a chloride current regulator and is important in regulating volume decrease after cellular swelling [, , , ].pLCln also functions as a Sm chaperone in the stepwise snRNP assembly process []. snRNPs is a RNA-protein complex esessential to the removal of introns from pre-mRNA [, ]. In humans, the core of snRNPs is composed of seven Sm proteins bound to snRNA. pLCln tethers the hetero-oligomers SmD1/D2 and SmE/F/G into a ring-shaped 6S complex, which subsequently docks onto the SMN complex. The SMN complex then removes pICln and enables the transfer of pre-assembled Sm proteins onto snRNA []. Consistent with the role of human pICln, the orthologue from S. pombe is required for optimal production of the spliceosomal snRNPs and for efficient splicing []. | Short Name: | ICln |
| GO Term | Gene Name |
|---|---|
| GO:0000387 | IPR003521 |
| GO:0006821 | IPR003521 |
| GO:0006884 | IPR003521 |
| GO:0005829 | IPR003521 |
| GO:0005886 | IPR003521 |
| GO:0034709 | IPR003521 |
| GO:0034715 | IPR003521 |
| GO Term | Gene Name |
|---|---|
| GO:0000387 | IPR003521 |
| GO:0006821 | IPR003521 |
| GO:0006884 | IPR003521 |
| GO:0005829 | IPR003521 |
| GO:0005886 | IPR003521 |
| GO:0034709 | IPR003521 |
| GO:0034715 | IPR003521 |
