Protein Domain : IPR013926

Type:  Family Name:  CGI121/TPRKB
Description:  This entry represents the EKC/KEOPS complex subunit Cgi121 from fungi and its homologue, TPRKB from mammals. Interestingly, this family also includes archaeal homologues []. CGI121 is part of the KEOPS complex, which is involved in is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t6A37) in tRNAs that read codons beginning with adenine []. The KEOPS complex also plays an important part in telomere uncapping and telomere elongation []. The complex is required for efficient recruitment of transcriptional coactivators []. TPRKB has been shown to bind to the p53-related protein kinase (PRPK) []. PRPK is a novel protein kinase which binds to and induces phosphorylation of the tumour suppressor protein p53. Short Name:  CGI121/TPRKB
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1 Child Features

DB identifier Type Name
IPR016799 Family Uncharacterised conserved protein UCP022062

0 Contains

2 Cross Referencess

Identifier
PTHR15840
PF08617

0 Found In

0 GO Annotation

0 Ontology Annotations

0 Parent Features

448 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
439257 D8R353 PAC:15422501 Selaginella moellendorffii 171  
30190.m011182 B9RC85 PAC:16823540 Ricinus communis 190  
Cucsa.244310.1 A0A0A0LBY8 PAC:16971287 Cucumis sativus 171  
orange1.1g040655m A0A067EXA9 PAC:18100119 Citrus sinensis 172  
AT4G34412.1 Q6NMZ4 PAC:19645147 Arabidopsis thaliana 172  
Thhalv10026394m V4MLQ7 PAC:20195656 Eutrema salsugineum 172  
Ciclev10029390m V4S764 PAC:20813090 Citrus clementina 172  
Lus10014052 PAC:23156866 Linum usitatissimum 172  
Lus10019861 PAC:23164051 Linum usitatissimum 172  
Potri.009G102200.1 PAC:26986357 Populus trichocarpa 172  
Potri.004G141400.2 B9N4X8 PAC:26989118 Populus trichocarpa 172  
Potri.004G141400.1 B9N4X8 PAC:26989117 Populus trichocarpa 172  
Potri.004G141400.3 PAC:26989119 Populus trichocarpa 148  
Gorai.002G008000.1 A0A0D2Q660 PAC:26793123 Gossypium raimondii 171  
Gorai.005G238200.1 A0A0D2NHP0 PAC:26804722 Gossypium raimondii 131  
61019 I0Z5V7 PAC:27390728 Coccomyxa subellipsoidea C-169 87  
153140 C1MP81 PAC:27347527 Micromonas pusilla CCMP1545 184  
63965 C1EGR3 PAC:27403731 Micromonas sp RCC299 174  
33384 A4S2A8 PAC:27413758 Ostreococcus lucimarinus 130  
Thecc1EG007059t1 A0A061E7N4 PAC:27463070 Theobroma cacao 194  
Thecc1EG007059t2 A0A061DZR1 PAC:27463071 Theobroma cacao 141  
Migut.N01188.1.p PAC:28924498 Mimulus guttatus 61  
Araha.1975s0005.1.p PAC:28845020 Arabidopsis halleri 149  
Cagra.6777s0011.1.p PAC:28894326 Capsella grandiflora 172  
Glyma.06G172100.1.p K7KVK2 PAC:30553129 Glycine max 171  
Glyma.06G172100.3.p K7KVK2 PAC:30553131 Glycine max 171  
Glyma.06G172100.2.p K7KVK2 PAC:30553130 Glycine max 171  
Glyma.04G194000.1.p C6T568 PAC:30488447 Glycine max 171  
Brara.K00346.1.p A0A397L0H4 PAC:30627542 Brassica rapa FPsc 172  
Brara.A00379.1.p A0A398AQC7 PAC:30637535 Brassica rapa FPsc 172  

4 Publications

First Author Title Year Journal Volume Pages PubMed ID
            21183954
            12659830
            16564010
            18951093