Protein Domain : IPR015419

Type:  Family Name:  CTAG/Pcc1 family
Description:  This entry represents the CTAG/Pcc1 family. Its members include yeast EKC/KEOPS complex subunit Pcc1, mammalian EKC/KEOPS complex subunit Lage3 and human cancer/testis antigen (CTAG) 1/2. In Saccharomyces cerevisiae, Pcc1 is a component of the EKC/KEOPS protein complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t6A37) in tRNAs that read codons beginning with adenine [].Similar to its S. cerevisiae homologue, human Lage3 is part of the EKC complex that is essential for a universal tRNA modification. The human EKC complex interacts with tumour antigen PRAME (preferentially expressed antigen in melanoma), and hence involved in oncogenesis []. Human CTAG 1 and 2 (also known as NY-ESO-1 and 2) share protein sequence similarity with Pcc1, however, their function is not clear. They are linked to cancer progression []. Short Name:  CTAG/Pcc1
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0 Child Features

0 Contains

1 Cross References

Identifier
PF09341

0 Found In

0 GO Annotation

0 Ontology Annotations

0 Parent Features

420 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
69858 D8R471 PAC:15420374 Selaginella moellendorffii 78  
29700.m000759 B9S7G1 PAC:16806098 Ricinus communis 92  
Cucsa.032250.1 PAC:16952422 Cucumis sativus 99  
Cucsa.032250.2 PAC:16952423 Cucumis sativus 60  
orange1.1g044191m A0A067DWJ1 PAC:18129779 Citrus sinensis 87  
AT5G53045.1 Q8GWD7 PAC:19671573 Arabidopsis thaliana 96  
Thhalv10022935m V4LJ58 PAC:20201935 Eutrema salsugineum 96  
Thhalv10015123m V4KYZ6 PAC:20203103 Eutrema salsugineum 96  
Ciclev10023204m V4TWQ5 PAC:20807799 Citrus clementina 70  
Ciclev10023496m V4T2F2 PAC:20807796 Citrus clementina 87  
Ciclev10024526m V4VNA2 PAC:20806350 Citrus clementina 89  
Ciclev10023672m V4TWQ9 PAC:20810705 Citrus clementina 97  
Lus10017942 PAC:23147866 Linum usitatissimum 88  
Potri.015G011500.2 PAC:27018004 Populus trichocarpa 92  
Potri.015G011500.1 B9IDP4 PAC:27018003 Populus trichocarpa 94  
Potri.012G017000.1 A0A2K1Y7E2 PAC:27050359 Populus trichocarpa 99  
Gorai.006G201800.1 A0A0D2RZG8 PAC:26829040 Gossypium raimondii 98  
58235 C1E518 PAC:27400658 Micromonas sp RCC299 149  
Thecc1EG015432t1 A0A061G2H6 PAC:27450406 Theobroma cacao 98  
Migut.F00201.1.p A0A022Q962 PAC:28932342 Mimulus guttatus 100  
Araha.32204s0001.1.p PAC:28852752 Arabidopsis halleri 96  
Cagra.0084s0051.1.p PAC:28895349 Capsella grandiflora 96  
Glyma.14G130500.1.p K7M6H6 PAC:30532315 Glycine max 72  
Glyma.14G131800.1.p K7M6I6 PAC:30535165 Glycine max 72  
Glyma.17G200500.1.p PAC:30479667 Glycine max 91  
Glyma.U011300.1.p PAC:30535298 Glycine max 91  
Brara.C01413.1.p A0A397ZXY2 PAC:30618537 Brassica rapa FPsc 96  
Brara.J00814.1.p A0A397XKJ8 PAC:30614258 Brassica rapa FPsc 96  
Bostr.26833s0977.1.p PAC:30653313 Boechera stricta 96  
Medtr1g007870.2 B7FN15 PAC:31099334 Medicago truncatula 93  

3 Publications

First Author Title Year Journal Volume Pages PubMed ID
            16874308
            22912744
            24970819