1 Contains
DB identifier | Type | Name |
---|---|---|
IPR018297 | Conserved_site | Adenylyl cyclase class-4/guanylyl cyclase, conserved site |
3 Ontology Annotations
GO Term | Gene Name |
---|---|
GO:0016849 | IPR001054 |
GO:0009190 | IPR001054 |
GO:0035556 | IPR001054 |
Type: | Domain | Name: | Adenylyl cyclase class-3/4/guanylyl cyclase |
Description: | Guanylate cyclases () catalyse the formation of cyclic GMP (cGMP) from GTP. cGMP acts as an intracellular messenger, activating cGMP-dependent kinases and regulating cGMP-sensitive ion channels. The role of cGMP as a second messenger in vascular smooth muscle relaxation and retinal photo-transduction is well established. Guanylate cyclase is found both in the soluble and particulate fractions of eukaryotic cells. The soluble and plasmamembrane-bound forms differ in structure, regulation and other properties [, , , ]. Most currently known plasma membrane-bound forms are receptors for small polypeptides. The soluble forms of guanylate cyclase arecytoplasmic heterodimers having alpha and beta subunits.In all characterised eukaryote guanylyl- and adenylyl cyclases, cyclic nucleotide synthesis is carried out by the conserved class III cyclase domain. | Short Name: | A/G_cyclase |
DB identifier | Type | Name |
---|---|---|
IPR018297 | Conserved_site | Adenylyl cyclase class-4/guanylyl cyclase, conserved site |
GO Term | Gene Name |
---|---|
GO:0016849 | IPR001054 |
GO:0009190 | IPR001054 |
GO:0035556 | IPR001054 |