Protein Domain : IPR029732

Type:  Family Name:  Pre-mRNA-splicing regulator WTAP
Description:  Pre-mRNA-splicing regulator WTAP (Wilms' tumor 1-associating protein) is a regulatory subunit of the WMM N6-methyltransferase complex, a multiprotein complex that mediates N6-methyladenosine (m6A) formation, which acts as an epitranscriptomic marker [, ]. It plays a role in the efficiency of mRNA splicing and processing, and mRNA stability []. In Drosophila, the homologous protein pfemale-lethal(2)D has been implicated in alternative splicing regulation of genes involved in sexual determination [] and is required for eye development [].This family also includes FKBP12-interacting protein of 37 kDa (AtFIP37, At3g54170) from Arabidopsis, which may also have a role in splicing events []. AtFIP37 interacts with mRNA adenosine methylase (MTA, encoded by At4g10760) in vitro and in vivo []. Short Name:  WTAP
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0 Child Features

0 Contains

1 Cross References

Identifier
PTHR15217:SF0

0 Found In

2 GO Annotations

GO Term Gene Name
GO:0048024 IPR029732
GO:0005634 IPR029732

2 Ontology Annotations

GO Term Gene Name
GO:0048024 IPR029732
GO:0005634 IPR029732

0 Parent Features

434 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
446134 D8SNY8 PAC:15420176 Selaginella moellendorffii 303  
evm.model.supercontig_35.80 PAC:16418203 Carica papaya 383  
30147.m013901 B9RAX6 PAC:16819916 Ricinus communis 338  
Cucsa.196650.1 PAC:16968289 Cucumis sativus 343  
orange1.1g019366m PAC:18132503 Citrus sinensis 342  
orange1.1g024197m PAC:18132504 Citrus sinensis 271  
AT3G54170.1 Q9ZSZ8 PAC:19660369 Arabidopsis thaliana 330  
Thhalv10010523m V4LRH8 PAC:20207708 Eutrema salsugineum 337  
Ciclev10020974m V4TTA9 PAC:20807824 Citrus clementina 342  
Ciclev10021573m V4TNA7 PAC:20807826 Citrus clementina 280  
Ciclev10021309m V4VK74 PAC:20807825 Citrus clementina 307  
Lus10039948 PAC:23173456 Linum usitatissimum 364  
Lus10042086 PAC:23153568 Linum usitatissimum 898  
Lus10027681 PAC:23151230 Linum usitatissimum 365  
Lus10018090 PAC:23148006 Linum usitatissimum 347  
Potri.002G197600.1 A0A2K2BLJ2 PAC:27020265 Populus trichocarpa 336  
Potri.002G197600.3 PAC:27020266 Populus trichocarpa 314  
Potri.002G197600.4 PAC:27020268 Populus trichocarpa 279  
Potri.002G197600.2 PAC:27020267 Populus trichocarpa 307  
Gorai.001G071300.3 A0A0D2N6I2 PAC:26824433 Gossypium raimondii 284  
Gorai.001G071300.4 A0A0D2QLR3 PAC:26824434 Gossypium raimondii 230  
Gorai.001G071300.5 A0A0D2LVQ3 PAC:26824432 Gossypium raimondii 302  
Gorai.001G071300.1 A0A0D2PVD2 PAC:26824430 Gossypium raimondii 346  
Gorai.001G071300.2 A0A0D2PMU8 PAC:26824431 Gossypium raimondii 340  
68118 I0YKS0 PAC:27395258 Coccomyxa subellipsoidea C-169 505  
Thecc1EG012212t1 A0A061FUE8 PAC:27449912 Theobroma cacao 348  
Migut.G00959.1.p PAC:28943196 Mimulus guttatus 356  
Migut.O00133.1.p PAC:28929789 Mimulus guttatus 271  
Araha.28276s0002.1.p PAC:28848642 Arabidopsis halleri 277  
Cagra.0562s0008.1.p PAC:28910786 Capsella grandiflora 306  

7 Publications

First Author Title Year Journal Volume Pages PubMed ID
            24407421
            12444081
            24690230
            24316715
            17088532
            15047892
            18505803