| Type: | Family | Name: | DNA repair protein Mre11 |
| Description: | Mre11 and Rad50 are two proteins required for DNA repair and meiosis-specific double-strand break formation in Saccharomyces cerevisiae. Mre11 by itself has 3' to 5' exonuclease activity that is increased when Mre11 is in a complex with Rad50 []. These eukaryotic proteins contain one metallo-phosphoesterase domain followed by an Mre11 DNA-binding domain. S. cerevisiae Mre11 is required for DNA repair and meiosis-specific double-strand break (DSB) formation [] and has both 3' to 5' exonuclease activity (whichincreases when in complex with Rad50) and endonuclease activity. The N-terminal phosphoesterase domain is required for DSB repair, and the carboxyl-terminal dsDNA-binding domain is essential during meiosis forchromatin modification and DSB formation []. Schizosaccharomyces pomberad32 is required for repair of double strand breaks and recombination [].For additional information please see []. | Short Name: | DNA_repair_Mre11 |
