Protein Domain : IPR012910

Type:  Domain Name:  TonB-dependent receptor, plug domain
Description:  In Escherichia colithe TonB protein interacts with outer membrane receptor proteins that carry out high-affinity binding and energy-dependent uptake of specific substrates into the periplasmic space []. These substrates are either poorly permeable through the porin channels or are encountered at very low concentrations. In the absence of TonB, these receptors bind their substrates but do not carry out active transport. TonB-dependent regulatory systems consist of six components: a specialised outer membrane-localized TonB-dependent receptor (TonB-dependent transducer) that interacts with its energizing TonB-ExbBD protein complex, a cytoplasmic membrane-localized anti-sigma factor and an extracytoplasmic function (ECF)-subfamily sigma factor []. The TonB complex senses signals from outside the bacterial cell and transmits them via two membranes into the cytoplasm, leading to transcriptional activation of target genes. The proteins that are currently known or presumed to interact with TonB include BtuB [], CirA, FatA, FcuT, FecA [], FhuA [], FhuE, FepA [], FptA, HemR, IrgA, IutA, PfeA, PupA and Tbp1. The TonB protein also interacts with some colicins. Most of these proteins contain a short conserved region at their N terminus [].This entry represents the plug domain, which has been shown to be an independently folding subunit of the TonB-dependent receptors []. It acts as the channel gate, blocking the pore until the channel is bound by a ligand. At this point it undergoes conformational changes and opens the channel. Short Name:  Plug_dom
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0 Child Features

0 Contains

2 Cross Referencess

Identifier
PF07715
G3DSA:2.170.130.10

7 Found Ins

DB identifier Type Name
IPR010105 Family TonB-dependent siderophore receptor
IPR010104 Family Bacterial TonB-dependent receptor
IPR010100 Family TonB-dependent copper receptor
IPR010101 Family TonB-dependent vitamin B12 transporter BtuB
IPR010948 Family TonB-dependent lactoferrin/transferrin receptor
IPR010949 Family TonB-dependent haemoglobin/transferrin/lactoferrin receptor
IPR011276 Family TonB-dependent haem/haemoglobin receptor

3 GO Annotations

GO Term Gene Name
GO:0004872 IPR012910
GO:0006810 IPR012910
GO:0016020 IPR012910

3 Ontology Annotations

GO Term Gene Name
GO:0004872 IPR012910
GO:0006810 IPR012910
GO:0016020 IPR012910

0 Parent Features

273 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
408190 D8R7H7 PAC:15419713 Selaginella moellendorffii 261  
30353.m000015 B9TLH1 PAC:16824368 Ricinus communis 288  
30363.m000015 B9TE62 PAC:16824379 Ricinus communis 476  
30853.m000021 B9TE01 PAC:16824661 Ricinus communis 372  
30753.m000026 B9TG14 PAC:16824594 Ricinus communis 135  
31052.m000014 B9TIR4 PAC:16824775 Ricinus communis 283  
31179.m000039 PAC:16824861 Ricinus communis 241  
31351.m000015 PAC:16824969 Ricinus communis 491  
31976.m000018 B9TJ11 PAC:16825265 Ricinus communis 274  
31842.m000015 PAC:16825202 Ricinus communis 429  
31901.m000014 B9TDA9 PAC:16825225 Ricinus communis 511  
32408.m000014 PAC:16825420 Ricinus communis 399  
32213.m000026 B9TCX0 PAC:16825334 Ricinus communis 296  
32227.m000022 B9TGE0 PAC:16825338 Ricinus communis 302  
32701.m000014 B9TG69 PAC:16825523 Ricinus communis 479  
32740.m000033 B9TER1 PAC:16825535 Ricinus communis 170  
32506.m000014 B9TDL6 PAC:16825453 Ricinus communis 514  
32985.m000014 B9TI02 PAC:16825633 Ricinus communis 417  
32988.m000014 B9TGE3 PAC:16825634 Ricinus communis 416  
32898.m000014 B9TJT9 PAC:16825609 Ricinus communis 256  
33244.m000018 PAC:16825744 Ricinus communis 537  
33464.m000022 PAC:16825853 Ricinus communis 203  
33623.m000030 B9TFE5 PAC:16825933 Ricinus communis 219  
34399.m000015 B9TKV6 PAC:16826203 Ricinus communis 372  
34677.m000028 B9TJU8 PAC:16826314 Ricinus communis 63  
35867.m000014 B9TI27 PAC:16826759 Ricinus communis 405  
40621.m000014 B9TJ64 PAC:16827324 Ricinus communis 363  
41840.m000013 B9TLV2 PAC:16827459 Ricinus communis 336  
42337.m000019 PAC:16827507 Ricinus communis 147  
41713.m000014 B9TNS9 PAC:16827434 Ricinus communis 119  

8 Publications

First Author Title Year Journal Volume Pages PubMed ID
            9886293
            14499604
            9865695
            12652322
            11872840
            12957833
            15993072
            15111112