Protein Domain : IPR000531

Type:  Domain Name:  TonB-dependent receptor, beta-barrel
Description:  In Escherichia colithe TonB protein interacts with outer membrane receptor proteins that carry out high-affinity binding and energy-dependent uptake of specific substrates into the periplasmic space []. These substrates are either poorly permeable through the porin channels or are encountered at very low concentrations. In the absence of TonB, these receptors bind their substrates but do not carry out active transport. TonB-dependent regulatory systems consist of six components: a specialised outer membrane-localised TonB-dependent receptor (TonB-dependent transducer) that interacts with its energising TonB-ExbBD protein complex, a cytoplasmic membrane-localised anti-sigma factor and an extracytoplasmic function (ECF)-subfamily sigma factor []. The TonB complex senses signals from outside the bacterial cell and transmits them via two membranes into the cytoplasm, leading to transcriptional activation of target genes. The proteins that are currently known or presumed to interact with TonB include BtuB [], CirA, FatA, FcuT, FecA [], FhuA [], FhuE, FepA [], FptA, HemR, IrgA, IutA, PfeA, PupA and Tbp1. The TonB protein also interacts with some colicins. Most of these proteins contain a short conserved region at their N terminus [].This entry covers the conserved part of the beta-barrel structure at the C-terminal. Short Name:  TonB-dep_rcpt_b-brl
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0 Child Features

1 Contains

DB identifier Type Name
IPR010917 Conserved_site TonB-dependent receptor, conserved site

2 Cross Referencess

Identifier
PF00593
G3DSA:2.40.170.20

7 Found Ins

DB identifier Type Name
IPR010105 Family TonB-dependent siderophore receptor
IPR010104 Family Bacterial TonB-dependent receptor
IPR010100 Family TonB-dependent copper receptor
IPR010101 Family TonB-dependent vitamin B12 transporter BtuB
IPR010948 Family TonB-dependent lactoferrin/transferrin receptor
IPR010949 Family TonB-dependent haemoglobin/transferrin/lactoferrin receptor
IPR011276 Family TonB-dependent haem/haemoglobin receptor

3 GO Annotations

GO Term Gene Name
GO:0004872 IPR000531
GO:0006810 IPR000531
GO:0016020 IPR000531

3 Ontology Annotations

GO Term Gene Name
GO:0004872 IPR000531
GO:0006810 IPR000531
GO:0016020 IPR000531

0 Parent Features

194 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
126225 PAC:15408233 Selaginella moellendorffii 419  
30409.m000022 B9TJI1 PAC:16824403 Ricinus communis 251  
30353.m000015 B9TLH1 PAC:16824368 Ricinus communis 288  
30363.m000015 B9TE62 PAC:16824379 Ricinus communis 476  
30610.m000024 B9TDZ6 PAC:16824508 Ricinus communis 129  
30666.m000018 B9TK04 PAC:16824537 Ricinus communis 212  
30853.m000021 B9TE01 PAC:16824661 Ricinus communis 372  
30858.m000015 B9TGG0 PAC:16824663 Ricinus communis 443  
30889.m000015 B9TDJ9 PAC:16824678 Ricinus communis 84  
30713.m000016 B9THV8 PAC:16824566 Ricinus communis 299  
30714.m000014 B9TEB4 PAC:16824567 Ricinus communis 524  
30758.m000014 B9TF99 PAC:16824600 Ricinus communis 491  
30793.m000015 B9TCY0 PAC:16824622 Ricinus communis 585  
31020.m000014 B9TH89 PAC:16824758 Ricinus communis 439  
30936.m000029 B9TCI2 PAC:16824713 Ricinus communis 179  
31193.m000014 B9TE74 PAC:16824877 Ricinus communis 471  
31179.m000039 PAC:16824861 Ricinus communis 241  
31454.m000012 B9TCX7 PAC:16825033 Ricinus communis 480  
31459.m000014 B9TJN3 PAC:16825037 Ricinus communis 74  
31351.m000015 PAC:16824969 Ricinus communis 491  
31553.m000014 B9TJX5 PAC:16825089 Ricinus communis 388  
31580.m000014 B9TG87 PAC:16825109 Ricinus communis 210  
31935.m000015 B9TJL7 PAC:16825244 Ricinus communis 378  
31940.m000021 B9TJ29 PAC:16825246 Ricinus communis 345  
31901.m000014 B9TDA9 PAC:16825225 Ricinus communis 511  
32408.m000014 PAC:16825420 Ricinus communis 399  
32191.m000018 PAC:16825330 Ricinus communis 337  
32213.m000026 B9TCX0 PAC:16825334 Ricinus communis 296  
32227.m000022 B9TGE0 PAC:16825338 Ricinus communis 302  
32628.m000015 B9THG8 PAC:16825500 Ricinus communis 414  

7 Publications

First Author Title Year Journal Volume Pages PubMed ID
            9886293
            14499604
            9865695
            12652322
            11872840
            12957833
            15993072