Protein Domain : IPR002773

Type:  Family Name:  Deoxyhypusine synthase
Description:  Eukaryotic initiation factor 5A (eIF-5A), now considered to be an elongation factor (see ), contains an unusual amino acid, hypusine [N epsilon-(4-aminobutyl-2-hydroxy)lysine]. The first step in thepost-translational formation of hypusine is catalysed by the enzyme deoxyhypusine synthase (DS) . The enzyme catalyses the following reaction: Spermidine + [eIF-5A]-lysine = 1,3-diaminopropane + [eIF-5A]-deoxyhypusine The modified version of eIF-5A, and DS, are required for eukaryotic cell proliferation []. The structure is known for this enzyme [] in complex with its NAD+cofactor. Short Name:  Deoxyhypusine_synthase
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2 Child Features

DB identifier Type Name
IPR022899 Family Deoxyhypusine synthase, putative, archaeal
IPR023496 Family Deoxyhypusine synthase-like

0 Contains

4 Cross Referencess

Identifier
PTHR11703
PF01916
TIGR00321
G3DSA:3.40.910.10

0 Found In

1 GO Annotation

GO Term Gene Name
GO:0008612 IPR002773

1 Ontology Annotations

GO Term Gene Name
GO:0008612 IPR002773

0 Parent Features

731 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
235300 D8SVY4 PAC:15405210 Selaginella moellendorffii 357  
evm.model.supercontig_19.251 PAC:16411996 Carica papaya 338  
29716.m000307 B9SW18 PAC:16806488 Ricinus communis 366  
Cucsa.317600.1 PAC:16977151 Cucumis sativus 366  
orange1.1g017671m A0A067EZL3 PAC:18126720 Citrus sinensis 368  
AT5G05920.1 Q9FI94 PAC:19670954 Arabidopsis thaliana 368  
AT5G05920.2 PAC:19670955 Arabidopsis thaliana 356  
Thhalv10013870m V4N510 PAC:20204605 Eutrema salsugineum 369  
Ciclev10008698m V4TVR5 PAC:20793182 Citrus clementina 368  
Lus10029688 PAC:23152028 Linum usitatissimum 840  
Lus10020239 PAC:23144200 Linum usitatissimum 229  
Lus10042728 PAC:23181856 Linum usitatissimum 362  
Lus10032793 PAC:23158965 Linum usitatissimum 83  
Potri.003G186900.1 B9GXM7 PAC:26996453 Populus trichocarpa 367  
Gorai.003G151600.3 A0A0D2NZK2 PAC:26797754 Gossypium raimondii 121  
Gorai.011G226400.1 A0A0D2UWP3 PAC:26812028 Gossypium raimondii 362  
Gorai.011G226300.3 A0A0D2UWV6 PAC:26806899 Gossypium raimondii 300  
Gorai.011G226300.2 A0A0D2VQG4 PAC:26806898 Gossypium raimondii 337  
Gorai.011G226300.1 A0A0D2UWN4 PAC:26806897 Gossypium raimondii 363  
11840 I0Z7A1 PAC:27393739 Coccomyxa subellipsoidea C-169 361  
180088 C1MZC3 PAC:27344067 Micromonas pusilla CCMP1545 367  
83166 C1E814 PAC:27402130 Micromonas sp RCC299 369  
35514 A4S0J4 PAC:27414191 Ostreococcus lucimarinus 342  
Thecc1EG042373t1 A0A061FKZ0 PAC:27443071 Theobroma cacao 366  
Thecc1EG042373t2 A0A061FSQ1 PAC:27443072 Theobroma cacao 305  
Migut.J00439.1.p A0A022RNG4 PAC:28941824 Mimulus guttatus 374  
Araha.0568s0014.1.p PAC:28845755 Arabidopsis halleri 367  
Cagra.2117s0070.1.p PAC:28905549 Capsella grandiflora 376  
Glyma.07G127600.2.p C6ZS20 PAC:30494684 Glycine max 384  
Glyma.07G127600.1.p C6ZS19 PAC:30494683 Glycine max 393  

1 Publications

First Author Title Year Journal Volume Pages PubMed ID
            9493264