3 Ontology Annotations
| GO Term | Gene Name |
|---|---|
| GO:0008137 | IPR007763 |
| GO:0009055 | IPR007763 |
| GO:0016020 | IPR007763 |
| Type: | Family | Name: | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 |
| Description: | NADH:ubiquinone oxidoreductase (complex I) () is a respiratory-chain enzyme that catalyses the transfer of two electrons from NADH to ubiquinone in a reaction that is associated with proton translocation across the membrane (NADH + ubiquinone = NAD+ + ubiquinol) []. Complex I is a major source of reactive oxygen species (ROS) that are predominantly formed by electron transfer from FMNH(2). Complex I is found in bacteria, cyanobacteria (as a NADH-plastoquinone oxidoreductase), archaea [], mitochondria, and in the hydrogenosome, a mitochondria-derived organelle. In general, the bacterial complex consists of 14 different subunits, while the mitochondrial complex contains homologues to these subunits in addition to approximately 31 additional proteins []. Mitochondrial complex I, which is located in the inner mitochondrial membrane, is the largest multimeric respiratory enzyme in the mitochondria, consisting of more than 45 subunits, one FMN co-factor and eight FeS clusters []. The assembly of mitochondrial complex I is an intricate process that requires the cooperation of the nuclear and mitochondrial genomes [, ]. Mitochondrial complex I can cycle between active and deactive forms that can be distinguished by the reactivity towards divalent cations and thiol-reactive agents. All redox prosthetic groups reside in the peripheral arm of the L-shaped structure. The NADH oxidation domain harbouring the FMN cofactor is connected via a chain of iron-sulphur clusters to the ubiquinone reduction site that is located in a large pocket formed by the PSST and 49kDa subunits of complex I [].This entry represents the NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 (NDUFA120)[], which is an accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I). NDUFA120 is believed not to be involved in catalysis []. | Short Name: | NDUFA12 |
| GO Term | Gene Name |
|---|---|
| GO:0008137 | IPR007763 |
| GO:0009055 | IPR007763 |
| GO:0016020 | IPR007763 |
