Protein Domain : IPR009212

Type:  Family Name:  Methylthioribose kinase
Description:  Members of this family are 5-methylthioribose kinases () that catalyse phosphorylation of 5-methylthioribose (MTR), a step in the recycling of methionine from 5'-methylthioadenosine, a co-product of polyamine biosynthesis. The preceding step of methylthioadenosine (MTA) hydrolysis to MTR is catalysed by 5'-methylthioadenosine/S-adenosylhomocysteine (MTA/AdoHcy) nucleosidase ().Bacillus subtilisprotein MtnK (formerly YkrT) [] and Klebsiella pneumoniaeprotein MtrK [] have been experimentally characterised. K. pneumoniae MtrK expression is regulated by methionine [].As this enzyme is absent in mammals, it has been considered a target for rational drug design. Short Name:  Methylthioribose_kinase
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0 Child Features

0 Contains

3 Cross Referencess

Identifier
PIRSF031134
TIGR01767
MF_01683

0 Found In

2 GO Annotations

GO Term Gene Name
GO:0046522 IPR009212
GO:0009086 IPR009212

2 Ontology Annotations

GO Term Gene Name
GO:0046522 IPR009212
GO:0009086 IPR009212

0 Parent Features

473 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
88229 D8R980 PAC:15404747 Selaginella moellendorffii 450  
evm.model.supercontig_106.101 PAC:16405153 Carica papaya 419  
29801.m003085 B9RY82 PAC:16808935 Ricinus communis 424  
Cucsa.244680.1 A0A0A0L6D2 PAC:16971335 Cucumis sativus 418  
AT1G49820.1 Q9C6D2 PAC:19657279 Arabidopsis thaliana 420  
Thhalv10011522m V4KT28 PAC:20184835 Eutrema salsugineum 418  
Ciclev10028867m V4UA92 PAC:20813988 Citrus clementina 314  
Ciclev10028518m V4SGN4 PAC:20813986 Citrus clementina 419  
Ciclev10028760m V4SBG9 PAC:20813987 Citrus clementina 344  
Potri.009G094800.1 A0A2K1Z5G4 PAC:26988026 Populus trichocarpa 418  
Potri.009G094800.2 PAC:26988027 Populus trichocarpa 343  
Potri.001G299700.1 A0A2K2C5Z2 PAC:27048624 Populus trichocarpa 418  
Gorai.008G022500.1 A0A0D2PMK9 PAC:26813925 Gossypium raimondii 419  
Gorai.008G022400.2 PAC:26814996 Gossypium raimondii 301  
Gorai.008G022400.1 PAC:26814995 Gossypium raimondii 416  
65695 I0Z044 PAC:27391122 Coccomyxa subellipsoidea C-169 1818  
57554 C1MR76 PAC:27346593 Micromonas pusilla CCMP1545 815  
54121 C1E0H5 PAC:27396312 Micromonas sp RCC299 799  
3520 A4S069 PAC:27414414 Ostreococcus lucimarinus 406  
Thecc1EG007151t2 A0A061E074 PAC:27463368 Theobroma cacao 419  
Thecc1EG007155t1 A0A061E016 PAC:27461014 Theobroma cacao 436  
Thecc1EG007151t1 A0A061E012 PAC:27463367 Theobroma cacao 441  
Migut.N01162.1.p A0A022RRS2 PAC:28923369 Mimulus guttatus 419  
Araha.61164s0001.1.p PAC:28858982 Arabidopsis halleri 419  
Cagra.18586s0001.1.p PAC:28900835 Capsella grandiflora 396  
Glyma.10G261300.3.p I1LEI7 PAC:30475456 Glycine max 342  
Glyma.10G261300.1.p I1LEI8 PAC:30475455 Glycine max 417  
Glyma.10G261300.2.p I1LEI8 PAC:30475454 Glycine max 417  
Glyma.01G244200.1.p K7K5M7 PAC:30542994 Glycine max 404  
Glyma.20G129700.1.p I1NFY2 PAC:30522599 Glycine max 417  

3 Publications

First Author Title Year Journal Volume Pages PubMed ID
            8694776
            8393067
            11545674