Type: | Domain | Name: | P2X purinoreceptor extracellular domain |
Description: | P2X purinoceptors are cell membrane ion channels, gated by adenosine 5'-triphosphate (ATP) and other nucleotides. P2X purinoceptor adopts a chalice-shaped, homotrimetric architecture consisting of a large hydrophilic and glycosylated extracellular domain, a transmembrane domain composed of 6 alpha-helices and short intracellular amino and carboxy termini [, ]. This entry represents the extracellular domain which is characterised by a transthyretin-like beta-sandwich motif []. This domain contains binding sites for ATP, competitive antagonists and modulatory metal ions []. | Short Name: | P2X_extracellular_dom |