Protein Domain : IPR016286

Type:  Family Name:  Alpha-L-fucosidase, metazoa-type
Description:  O-Glycosyl hydrolases family 29 () encompasses alpha-L-fucosidases () [], which is a lysosomal enzyme responsible for hydrolysing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins. Alpha-L-fucosidase is responsible for hydrolysing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins.Fucosylated glycoconjugates are involved in numerous biological events, making alpha-l-fucosidases, the enzymes responsible for their processing, critically important. Deficiency in alpha-l-fucosidase activity is associated with fucosidosis, a lysosomal storage disorder characterised by rapid neurodegeneration, resulting in severe mental and motor deterioration []. The enzyme is a hexamer and displays a two-domain fold, composed of a catalytic (beta/alpha)(8)-like domain and a C-terminal beta-sandwich domain [].Drosophila melanogasterspermatozoa contains an alpha-l-fucosidase that might be involved in fertilisation by interacting with alpha-l-fucose residues on the micropyle of the eggshell []. In human sperm, membrane-associated alpha-l-fucosidase is stable for extended periods of time, which is made possible by membrane domains and compartmentalisation. These help preserve protein integrity [].This entry represents a subgroup of alpha-L-fucosidases found in metazoa, fungi and bacteria, but that excludes alpha-L-fucosidases from plants. Short Name:  FUC_metazoa-typ

2 Child Features

DB identifier Type Name
IPR028755 Family Tissue alpha-L-fucosidase
IPR028756 Family Plasma alpha-L-fucosidase

1 Contains

DB identifier Type Name
IPR018526 Conserved_site Glycoside hydrolase, family 29, conserved site

2 Cross Referencess

Identifier
PIRSF001092
PR00741

0 Found In

2 GO Annotations

GO Term Gene Name
GO:0004560 IPR016286
GO:0006004 IPR016286

2 Ontology Annotations

GO Term Gene Name
GO:0004560 IPR016286
GO:0006004 IPR016286

1 Parent Features

DB identifier Type Name
IPR000933 Family Glycoside hydrolase, family 29

44 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
orange1.1g011170m A0A067FDB9 PAC:18127824 Citrus sinensis 492  
orange1.1g047217m A0A067F9X3 PAC:18104389 Citrus sinensis 364  
Ciclev10004832m V4U6Z1 PAC:20791978 Citrus clementina 492  
Cagra.1433s0008.1.p PAC:28916639 Capsella grandiflora 504  
Glyma.10G241800.1.p I1LDX9 PAC:30475228 Glycine max 487  
Glyma.10G241800.2.p I1LDX9 PAC:30475229 Glycine max 487  
Glyma.20G152400.1.p I1NGM2 PAC:30523346 Glycine max 487  
Spipo1G0027300 PAC:31521002 Spirodela polyrhiza 465  
Kalax.0201s0013.1.p PAC:32540496 Kalanchoe laxiflora 528  
Kalax.0081s0018.1.p PAC:32594526 Kalanchoe laxiflora 529  
Kalax.0858s0010.1.p PAC:32536632 Kalanchoe laxiflora 498  
Mapoly0010s0119.1.p A0A2R6XKT9 PAC:33022049 Marchantia polymorpha 491  
Kaladp0055s0375.1.p PAC:35757551 Kalanchoe fedtschenkoi 498  
Kaladp0045s0152.1.p PAC:35781084 Kalanchoe fedtschenkoi 528  
Anaoc.0010s0262.1.p PAC:37555375 Anacardium occidentale 437  
Anaoc.0018s0333.1.p PAC:37487123 Anacardium occidentale 488  
Anaoc.0229s0004.1.p PAC:37532637 Anacardium occidentale 437  
Oeu039224.1 PAC:37702610 Olea europaea 436  
evm.model.Scaffold_637.1869 PAC:37878040 Coffea arabica 508  
evm.model.Scaffold_637.1024 PAC:37876579 Coffea arabica 509  
Lsat_1_v5_gn_6_44060.1 A0A2J6JG64 PAC:38939264 Lactuca sativa 537  
Carub.0004s0887.1.p R0HNY3 PAC:39237214 Capsella rubella 504  
Isati.15199s0001.1.p PAC:39284223 Isatis tinctoria 342  
Bobra.67_1s0048.1.p PAC:40721725 Botryococcus braunii 383  
Vigun07g232700.1.p PAC:43123670 Vigna unguiculata 491  
VuSuvita2.07G226400.1.p PAC:43137547 Vigna unguiculata Suvita2 491  
VuUCR779.07G224800.1.p PAC:43237322 Vigna unguiculata UCR779 491  
VuSanzi.07G222900.1.p PAC:43280928 Vigna unguiculata Sanzi 491  
VuCB5-2.07G225900.1.p PAC:43314929 Vigna unguiculata CB5-2 491  
VuTZ30.07G219500.1.p PAC:44143894 Vigna unguiculata TZ30 491  

4 Publications

First Author Title Year Journal Volume Pages PubMed ID
            2482732
            14715651
            18556148
            18522672