Protein Domain : IPR000366

Type:  Family Name:  GPCR fungal pheromone mating factor, STE2
Description:  G protein-coupled receptors (GPCRs) constitute a vast protein family that encompasses a wide range of functions, including various autocrine, paracrine and endocrine processes. They show considerable diversity at the sequence level, on the basis of which they can be separated into distinct groups []. The term clan can be used to describe the GPCRs, as they embrace a group of families for which there are indications of evolutionary relationship, but between which there is no statistically significant similarity in sequence []. The currently known clan members include rhodopsin-like GPCRs (Class A, GPCRA), secretin-like GPCRs (Class B, GPCRB), metabotropic glutamate receptor family (Class C, GPCRC), fungal mating pheromone receptors (Class D, GPCRD), cAMP receptors (Class E, GPCRE) and frizzled/smoothened (Class F, GPCRF) [, , , , ]. GPCRs are major drug targets, and are consequently the subject of considerable research interest. It has been reported that the repertoire of GPCRs for endogenous ligands consists of approximately 400 receptors in humans and mice []. Most GPCRs are identified on the basis of their DNA sequences, rather than the ligand they bind, those that are unmatched to known natural ligands are designated by as orphan GPCRs, or unclassified GPCRs [].GPCR Fungal pheromone mating factor receptors form a distinct family of G-protein-coupled receptors, and are also known as Class D GPCRs.The Fungal pheromone mating factor receptors STE2 and STE3 are integral membrane proteins that may be involved in the response to mating factors on the cell membrane [, , ]. The amino acid sequences of both receptors contain high proportions of hydrophobic residues grouped into 7 domains,in a manner reminiscent of the rhodopsins and other receptors believed tointeract with G-proteins. However, while a similar 3D framework has been proposed to account for this, there is no significant sequence similarity either between STE2 and STE3, or between these and the rhodopsin-type family: the receptors thereofore bear their own unique '7TM' signatures which is why they have been given their own GPCR group: Class D Fungal mating pheromone receptors.This entry represents the STE2-type family of GPCR. The STE2 gene of Saccharomyces cerevisiae(Baker's yeast) is the cell-surface receptor that binds the 13-residue lipopeptide a-factor. Short Name:  GPCR_STE2
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0 Child Features

0 Contains

2 Cross Referencess

Identifier
PF02116
PR00250

0 Found In

3 GO Annotations

GO Term Gene Name
GO:0004932 IPR000366
GO:0007186 IPR000366
GO:0016020 IPR000366

3 Ontology Annotations

GO Term Gene Name
GO:0004932 IPR000366
GO:0007186 IPR000366
GO:0016020 IPR000366

0 Parent Features

6 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
Kalax.0069s0043.1.p PAC:32576643 Kalanchoe laxiflora 159  
Solyc06g009990.1.1 PAC:36129592 Solanum lycopersicum 371  
MgNONTOL.D2364.1.p PAC:43592340 Mimulus guttatus NONTOL 498  
MgNONTOL.M0824.1.p PAC:43605577 Mimulus guttatus NONTOL 996  
MgNONTOL.O0824.1.p PAC:43608036 Mimulus guttatus NONTOL 623  
Thupl.29380369s0002.1.p PAC:45002151 Thuja plicata 271  

10 Publications

First Author Title Year Journal Volume Pages PubMed ID
            8170923
            16753280
            23020293
            12679517
            8081729
            15914470
            18948278
            16453635
            3001640
            2836861