Protein Domain : IPR002186

Type:  Family Name:  Neocarzinostatin family
Description:  This family is comprised of antitumour antibiotic chromoproteins, as represented by neocarzinostatin []. These chromoproteins consist of a noncovalently bound, labile enediyne chromophore and its stabilising carrier apoprotein. The protein component of the chromophore displays an unusual bicyclic dienediyne structure. The chromoprotein inter-chelates the DNA, where its cycloaromatisation produces a biradical intermediate that has the ability to abstract hydrogens from the sugar moiety of DNA. This causes single- and double-strand breaks in the DNA []. In addition to their ability to cleave DNA at sites specific for each chromophore, results indicate that these chromoproteins also possess proteolytic activity against histones, with histone H1 as the preferred substrate [].Neocarzinostatin has 2 disulphide bridges and is kidney-shaped with 2 defined domains that hold a binding cavity. The larger domain forms a 7-stranded antiparallel beta-barrel and the smaller domain consists of 2 anti-parallel strands of beta sheet that are perpendicular to each other []. Other members of this family include macromycin, actinoxanthine, kedarcidin [], and C-1027 []. Short Name:  Neocarzinostatin_fam
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0 Child Features

0 Contains

3 Cross Referencess

Identifier
PF00960
PR01885
PD012709

0 Found In

2 GO Annotations

GO Term Gene Name
GO:0003677 IPR002186
GO:0006952 IPR002186

2 Ontology Annotations

GO Term Gene Name
GO:0003677 IPR002186
GO:0006952 IPR002186

0 Parent Features

6 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
Sevir.4G184100.1.p A0A4U6UYV4 PAC:32647050 Setaria viridis 418  
Seita.4G133100.1.p A0A368QTR8 PAC:32707604 Setaria italica 418  
Zm00008a036006_P01 PAC:37179865 Zea mays PH207 503  
PhHAL.4G243200.1.p PAC:40420185 Panicum hallii HAL 496  
Sevir.4G184100.1.p A0A4U6UYV4 PAC:40600878 Setaria viridis 418  
PhHAL.4G243200.1.p PAC:45968966 Panicum hallii HAL 496  

3 Publications

First Author Title Year Journal Volume Pages PubMed ID
            8235619
            11491295
            9383447