Protein Domain : IPR018385

Type:  Family Name:  C4-dicarboxylate anaerobic carrier-like
Description:  Escherichia colicontains four different secondary carriers (DcuA, DcuB, DcuC, and DctA) for C4-dicarboxylates [, , , ] DcuA is used for aerobic growth on C4-dicarboxylates [, ], whereas the Dcu carriers (encoded by the dcuA, dcuB, and dcuC genes) are used under anaerobic conditions and form a distinct family of carriers [, , , , , ]. Each of the Dcu carriers is able to catalyze the uptake, antiport, and possibly also efflux of C4-dicarboxylates. DcuB is the major C4-dicarboxylate carrier for fumarate respiration with high fumarate-succinate exchange activity. It is synthesized only in the absence of oxygen and nitrate and in the presence of C4-dicarboxylates [, , , ]. DcuA is expressed constitutively in aerobic and anaerobic growth and can substitute for DcuB [, ]. These proteins are members of the C4-dicarboxylate Uptake C (DcuC) family. DcuC has 12 GES predicted transmembrane regions, is induced only under anaerobic conditions, and is not repressed by glucose. DcuC may therefore function as a succinate efflux system during anaerobic glucose fermentation. However, when overexpressed, it can replace either DcuA or DcuB in catalyzing fumarate-succinate exchange and fumarate uptake [, ]. DcuC shows the same transport modes as DcuA and DcuB (exchange, uptake, and presumably efflux of C4-dicarboxylates) []. Short Name:  C4_dicarb_anaerob_car-like
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1 Child Features

DB identifier Type Name
IPR004669 Family C4-dicarboxylate anaerobic carrier

0 Contains

1 Cross References

Identifier
PF03606

0 Found In

1 GO Annotation

GO Term Gene Name
GO:0016021 IPR018385

1 Ontology Annotations

GO Term Gene Name
GO:0016021 IPR018385

0 Parent Features

5 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
Pp3s30_70V3.1.p PAC:32948429 Physcomitrium patens 1902  
Pp3s46_160V3.2.p PAC:32948228 Physcomitrium patens 468  
Pp3s46_160V3.1.p PAC:32948227 Physcomitrium patens 855  
Pp3s34_760V3.1.p PAC:32948289 Physcomitrium patens 341  
Brdisv1BdTR11A1041173m.p PAC:35693250 Brachypodium distachyon BdTR11a 922  

12 Publications

First Author Title Year Journal Volume Pages PubMed ID
            7961398
            9852003
            9889977
            9765574
            10482502
            1512189
            8955408
            5541510
            8020497
            9230919
            9973351
            10368146