Protein Domain : IPR012703

Type:  Family Name:  2-aminoethylphosphonate--pyruvate transaminase
Description:  Phosphonates are a class of organophosphorus compounds, characterised by a stable C-P bond, which are found in a variety of biologically produced molecules including antiobiotics, lipids, proteins and polysaccharides []. The functions of these molecules include phosphorus storage, cell communication, host recognition and chemical warfare. 2-Aminoethylphosphonate (AEP), the most common naturally occurring phosphonate, is an important precursor used in the biosynthesis of phosphonolipids, phosphonoproteins, and phosphonoglycans.This entry represents 2-aminoethylphosphonate-pyruvate transaminase (AEPT) () which catalyses the interconversion of AEP and phosphonoacetaldehyde (P-Ald), coupled with the interconversion of pryuvate and L-alanine. In some bacterial species this is the first step in an AEP degradation pathway which allows them to utilise this compound as a source of carbon, nitrogen and phosphorus. Phosphonoacetaldeyhde hydrolase, often encoded by an adjacent gene, then converts P-Ald to acetaldehyde and phosphate. Species with this pathway generally have an identified phosphonate ABC transporter but do not also have the multisubunit C-P lyase complex as found in Escherichia coli.The crystal structure of AEPT from Salmonella typhimuriumhas been studied to 2.2 A resolution []. The protein is a homodimer where each subunit is composed of two domains, large and small. The large domain forms an alpha-beta complex characteristic of the aspartate transaminase family, while the small domain is composed of highly twisted beta strands. The active site contains a pyridoxal 5'-phosphate cofactor and is found at the domain interface, being composed of residues from both subunits. Short Name:  NH2EtPonate_pyrv_transaminase
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0 Child Features

1 Contains

DB identifier Type Name
IPR015421 Domain Pyridoxal phosphate-dependent transferase, major region, subdomain 1

3 Cross Referencess

Identifier
TIGR02326
TIGR03301
MF_01376

0 Found In

2 GO Annotations

GO Term Gene Name
GO:0047304 IPR012703
GO:0019700 IPR012703

2 Ontology Annotations

GO Term Gene Name
GO:0047304 IPR012703
GO:0019700 IPR012703

1 Parent Features

DB identifier Type Name
IPR024169 Family Serine-pyruvate aminotransferase/2-aminoethylphosphonate-pyruvate transaminase

2 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
Pp3s34_170V3.1.p PAC:32948266 Physcomitrium patens 1778  
Pp3s34_610V3.1.p PAC:32948312 Physcomitrium patens 2078  

2 Publications

First Author Title Year Journal Volume Pages PubMed ID
            11952414
            12403617