Protein Domain : IPR017742

Type:  Family Name:  7-carboxy-7-deazaguanine synthase
Description:  7-deazapurines are compounds that contain pyrrolopyrimidine functional groups (similar to purines, but lacking one of the nitrogens in the pentameric ring). These compounds form a structurally diverse class of nucleoside analogues that often possess antibiotic, antineoplastic, or antiviral activities. Examples of 7-deazapurines that are important for cell function include the bacterial/eukaryotic modified tRNA base queuosine and the archaeal modified base archaeosine. 7-cyano-7-deazaguanosine (preQ0) is the precursor for all 7-deazapurines and is produced from GTP in a four-step pathway [, ]. 7-carboxy-7-deazaguanine synthase catalyses the third step in this pathway, the conversion of 6-carboxy-5,6,7,8-tetrahydropterin to 7-carboxy-7-deazaguanine. Short Name:  Deazaguanine_synth
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0 Child Features

1 Contains

DB identifier Type Name
IPR007197 Domain Radical SAM

1 Cross References

Identifier
TIGR03365

0 Found In

0 GO Annotation

0 Ontology Annotations

1 Parent Features

DB identifier Type Name
IPR024924 Family 7-carboxy-7-deazaguanine synthase-like

2 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
Pp3s34_510V3.2.p PAC:32948300 Physcomitrium patens 429  
Pp3s34_520V3.1.p PAC:32948287 Physcomitrium patens 391  

2 Publications

First Author Title Year Journal Volume Pages PubMed ID
            14660578
            19354300