Protein Domain : IPR003796

Type:  Family Name:  Ribonucleotide reductase regulator NrdR-like
Description:  Ribonucleotide reductases (RNRs) are essential enzymes which catalyse the reduction of ribonucleotides to their respective deoxyribonucleotides, thus providing the precursors necessary for DNA synthesis [].Proteins in this entry are orthologues of the novel transcriptional regulator NrdR () from Streptomyces coelicolor. This protein negatively regulates the expression of the RNR genes in this organism []. NrdR, like all proteins in this entry, contains an ATP-cone domain which may regulate DNA-binding activity by sensing deoxyribonucleotides [], though since this domain resembles the allosteric effector region of some RNRs it has also been suggested that it may allow NrdR to directly modulate the activity of some reductases, in addition to its function as a transcriptional regulator [].NrdR-type proteins have been detected in a large number of bacterial genomes []. They are encoded only once in any particular genome and are usually clustered near RNR genes or genes involved in chromosome replication. Currently, only a single archaeon Natronomonas pharaonis(strain DSM 2160/ATCC 35678) has been shown to encode one of these proteins. Short Name:  RNR_NrdR-like
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0 Child Features

1 Contains

DB identifier Type Name
IPR005144 Domain ATP-cone domain

2 Cross Referencess

Identifier
TIGR00244
MF_00440

0 Found In

2 GO Annotations

GO Term Gene Name
GO:0008270 IPR003796
GO:0045892 IPR003796

2 Ontology Annotations

GO Term Gene Name
GO:0008270 IPR003796
GO:0045892 IPR003796

0 Parent Features

1 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
Pp3s58_20V3.1.p PAC:32929841 Physcomitrium patens 161  

3 Publications

First Author Title Year Journal Volume Pages PubMed ID
            8511586
            15522084
            15949864