Protein Domain : IPR001531

Type:  Domain Name:  Phospholipase C domain
Description:  Bacillus cereuscontains a monomeric phospholipase C (PLC) of 245 amino-acid residues that binds three zinc ions []. Although PLC prefers to act on phosphatidylcholine, it also shows weak catalytic activity with sphingomyelin and phosphatidylinositol []. Sequence studies have shown the PLC protein to be similar to the following:Alpha toxin from Clostridium perfringensand Clostridium bifermentans, which are zinc-dependent phospholipases C involved in haemolysis and cell rupture [].Lecithinase C from Listeria monocytogenes, which aids cell-to-cell spread by breaking down the 2-membrane vacuoles that surround the bacterium during transfer [].Each of these proteins is a zinc-dependent enzyme, binding 3 zinc ions per molecule []. The enzymes catalyse the conversion of phosphatidylcholine and water to 1,2-diacylglycerol and choline phosphate [, , ]. In B. cereus, there are nine residues known to be involved in binding the zinc ions: 5 His, 2 Asp, 1 Glu and 1 Trp. These residues are all conserved in the Clostridium alpha-toxin []. Short Name:  PLipaseC_domain
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0 Child Features

0 Contains

5 Cross Referencess

Identifier
PR00479
PD003946
PS00384
PS51346
SM00770

0 Found In

2 GO Annotations

GO Term Gene Name
GO:0004629 IPR001531
GO:0008270 IPR001531

2 Ontology Annotations

GO Term Gene Name
GO:0004629 IPR001531
GO:0008270 IPR001531

1 Parent Features

DB identifier Type Name
IPR008947 Domain Phospholipase C/P1 nuclease domain

4 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
Mapoly0022s0127.1.p A0A2R6XD44 PAC:33010976 Marchantia polymorpha 164  
Oeu046703.1 PAC:37739995 Olea europaea 773  
AH021145-RA PAC:38166524 Amaranthus hypochondriacus 292  
AH014239-RA PAC:38176482 Amaranthus hypochondriacus 301  

6 Publications

First Author Title Year Journal Volume Pages PubMed ID
            2841128
            2111259
            2536355
            1309513
            2493587
            9699639