Protein Domain : IPR015338

Type:  Domain Name:  Exostosin , C-terminal
Description:  This entry represents the C-terminal domain of exostosins (EXTs), which belong to the glycosyltransferase 47 family. In humans, there are five exostosins identified, including EXT1-2, EXTL1-3. They are glycosyltransferases required for the biosynthesis of heparan-sulfate []. They may be tumour suppressors in humans []. EXTL2 catalyses the transfer reaction of N-acetylglucosamine and N-acetylgalactosamine from the respective UDP-sugars to the non-reducing end of [glucuronic acid]beta 1-3[galactose]beta 1-O-naphthalenemethanol, an acceptor substrate analogue of the natural common linker of various glycosylaminoglycans. They are also required for the biosynthesis of heparan-sulphate []. This domain is also found in Arabidopsis glycosyltransferase 64 family members []. Short Name:  EXT_C
Paste the following link

0 Child Features

0 Contains

1 Cross References

Identifier
PF09258

0 Found In

3 GO Annotations

GO Term Gene Name
GO:0006024 IPR015338
GO:0015012 IPR015338
GO:0016021 IPR015338

3 Ontology Annotations

GO Term Gene Name
GO:0006024 IPR015338
GO:0015012 IPR015338
GO:0016021 IPR015338

1 Parent Features

DB identifier Type Name
IPR029044 Domain Nucleotide-diphospho-sugar transferases

3256 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
81258 D8QZ13 PAC:15406733 Selaginella moellendorffii 273  
420395 D8SBV5 PAC:15412251 Selaginella moellendorffii 279  
139351 PAC:15402714 Selaginella moellendorffii 702  
133103 D8T6I2 PAC:15405874 Selaginella moellendorffii 339  
403218 D8QTG3 PAC:15405610 Selaginella moellendorffii 314  
evm.model.supercontig_128.65 PAC:16407492 Carica papaya 335  
evm.model.supercontig_19.204 PAC:16411944 Carica papaya 290  
evm.model.supercontig_4.178 PAC:16419261 Carica papaya 360  
evm.model.supercontig_488.3 PAC:16420998 Carica papaya 343  
30147.m014149 B9R9K7 PAC:16820162 Ricinus communis 290  
29669.m000810 B9SLJ9 PAC:16805237 Ricinus communis 329  
29589.m001291 B9SCN4 PAC:16803331 Ricinus communis 349  
27916.m000159 B9T3V5 PAC:16799511 Ricinus communis 704  
Cucsa.368680.1 PAC:16981710 Cucumis sativus 262  
Cucsa.308870.1 A0A0A0KTH2 PAC:16976421 Cucumis sativus 783  
Cucsa.308870.2 PAC:16976422 Cucumis sativus 558  
Cucsa.311230.1 PAC:16976651 Cucumis sativus 307  
orange1.1g020041m A0A067FSA3 PAC:18138360 Citrus sinensis 332  
orange1.1g045656m A0A067EJQ7 PAC:18110363 Citrus sinensis 802  
AT5G04500.1 Q84WB7 PAC:19665903 Arabidopsis thaliana 765  
AT3G55830.1 Q9LY62 PAC:19665032 Arabidopsis thaliana 334  
AT1G80290.1 Q9C975 PAC:19649302 Arabidopsis thaliana 329  
AT1G80290.2 Q9C975 PAC:19649301 Arabidopsis thaliana 337  
Thhalv10000547m V4LR26 PAC:20208400 Eutrema salsugineum 302  
Thhalv10010522m V4NFG0 PAC:20206811 Eutrema salsugineum 338  
Thhalv10012710m V4N4N8 PAC:20204599 Eutrema salsugineum 813  
Ciclev10010680m V4UBE2 PAC:20795703 Citrus clementina 339  
Ciclev10030719m V4T9A6 PAC:20805590 Citrus clementina 814  
Ciclev10032067m V4SMC2 PAC:20803587 Citrus clementina 332  
Lus10028274 PAC:23166557 Linum usitatissimum 330  

3 Publications

First Author Title Year Journal Volume Pages PubMed ID
            12562774
            11518722
            16045474