| Type: | Domain | Name: | UmuC domain |
| Description: | In Escherichia coli, UV and many chemicals appear to cause mutagenesis by a process of translesion synthesis that requires DNA polymerase III and the SOS-regulated proteins UmuD, UmuC and RecA. This machinery allows the replication to continue through DNA lesion, and therefore avoid lethal interruption of DNA replication after DNA damage []. UmuC is a well conserved protein in prokaryotes, with a homologue in yeast species.Proteins known to contain an UmuC domain are listed below: E. coli MucB protein. Plasmid-born analogue of the UmuC protein.Saccharomyces cerevisiae(Baker's yeast) Rev1 protein. Homologue of UmuC also required for normal induction of mutations by physical and chemical agents. Salmonella typhimuriumImpB protein. Plasmid-born analogue of the UmuC protein.Bacterial UmuC protein.E. coli DNA-damage-inducible protein P (DinP).S. typhimurium SamB homologue of UmuC plasmid associated. | Short Name: | UmuC |
