Protein Domain : IPR001356

Type:  Domain Name:  Homeobox domain
Description:  The homeobox domain or homeodomain was first identified in a number of drosophila homeotic and segmentation proteins, but is now known to be well-conserved in many other animals, including vertebrates [, ]. Hox genes encode homeodomain-containing transcriptional regulators that operate differential genetic programs along the anterior-posterior axis of animal bodies []. The domain binds DNA through a helix-turn-helix (HTH) structure. The HTH motif is characterised by two alpha-helices, which make intimate contacts with the DNA and are joined by a short turn. The second helix binds to DNA via a number of hydrogen bonds and hydrophobic interactions, which occur between specific side chains and the exposed bases and thymine methyl groups within the major groove of the DNA. The first helix helps to stabilise the structure. The motif is very similar in sequence and structure in a wide range of DNA-binding proteins (e.g., cro and repressor proteins, homeotic proteins, etc.). One of the principal differences between HTH motifs in these different proteins arises from the stereo-chemical requirement for glycine in the turn which is needed to avoid steric interference of the beta-carbon with the main chain: for cro and repressor proteins the glycine appears to be mandatory, while for many of the homeotic and other DNA-binding proteins the requirement is relaxed. Short Name:  Homeobox_dom
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2 Child Features

DB identifier Type Name
IPR008422 Domain Homeobox KN domain
IPR020479 Domain Homeodomain, metazoa

2 Contains

DB identifier Type Name
IPR000047 Conserved_site Helix-turn-helix motif
IPR017970 Conserved_site Homeobox, conserved site

3 Cross Referencess

Identifier
PF00046
PS50071
SM00389

10 Found Ins

DB identifier Type Name
IPR017112 Family Homeobox protein Hox9
IPR016362 Family POU-domain transcription factor, class 3
IPR016233 Family Homeobox protein Pitx/unc30
IPR000972 Family Octamer-binding transcription factor
IPR015584 Family POU domain-containing protein, class 4-related
IPR015585 Family POU domain-containing protein, class 5
IPR015586 Family Pituitary-specific positive transcription factor 1
IPR003022 Family Transcription factor Otx2
IPR003025 Family Transcription factor Otx
IPR003026 Family Transcription factor Otx1

1 GO Annotation

GO Term Gene Name
GO:0003677 IPR001356

1 Ontology Annotations

GO Term Gene Name
GO:0003677 IPR001356

1 Parent Features

DB identifier Type Name
IPR009057 Domain Homeodomain-like

37718 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
18196 D8RGY1 PAC:15420843 Selaginella moellendorffii 104  
135843 D8TAX2 PAC:15417235 Selaginella moellendorffii 275  
19476 D8RLG4 PAC:15403593 Selaginella moellendorffii 87  
270954 Q0Q432 PAC:15401824 Selaginella moellendorffii 840  
404134 D8QUD7 PAC:15407758 Selaginella moellendorffii 312  
4561 PAC:15416615 Selaginella moellendorffii 168  
39529 PAC:15418759 Selaginella moellendorffii 63  
415291 D8RVM5 PAC:15418930 Selaginella moellendorffii 336  
438630 D8QX61 PAC:15422614 Selaginella moellendorffii 582  
80869 D8QYH2 PAC:15408409 Selaginella moellendorffii 293  
417475 D8S2C3 PAC:15403765 Selaginella moellendorffii 105  
417553 D8S2U5 PAC:15404493 Selaginella moellendorffii 268  
39729 PAC:15420274 Selaginella moellendorffii 64  
405582 D8QZ18 PAC:15414078 Selaginella moellendorffii 546  
81609 D8R0G9 PAC:15409700 Selaginella moellendorffii 127  
115439 D8SF49 PAC:15421978 Selaginella moellendorffii 86  
17503 D8SEU6 PAC:15420747 Selaginella moellendorffii 143  
422900 D8SJX2 PAC:15422371 Selaginella moellendorffii 603  
39737 PAC:15420295 Selaginella moellendorffii 61  
407131 D8R404 PAC:15416619 Selaginella moellendorffii 248  
84611 PAC:15418508 Selaginella moellendorffii 89  
446032 D8SN55 PAC:15419393 Selaginella moellendorffii 1010  
407891 D8R539 PAC:15422007 Selaginella moellendorffii 236  
139631 D8QQV4 PAC:15404959 Selaginella moellendorffii 185  
270225 D8QNI3 PAC:15418749 Selaginella moellendorffii 855  
402076 D8QPI1 PAC:15401285 Selaginella moellendorffii 481  
447019 D8SW30 PAC:15422177 Selaginella moellendorffii 1495  
77000 D8QT80 PAC:15415552 Selaginella moellendorffii 821  
159366 D8SY74 PAC:15417225 Selaginella moellendorffii 413  
18217 D8RC65 PAC:15421310 Selaginella moellendorffii 87  

3 Publications

First Author Title Year Journal Volume Pages PubMed ID
            2568852
            1357790
            12445403