Protein Domain : IPR012336

Type:  Domain Name:  Thioredoxin-like fold
Description:  Several biological processes regulate the activity of target proteins through changes in the redox state of thiol groups (S2 to SH2), where a hydrogen donor is linked to an intermediary disulphide protein. Such processes include the ferredoxin/thioredoxin system, the NADP/thioredoxin system, and the glutathione/glutaredoxin system []. Several of these disulphide proteins share a common structure, consisting of a three-layer alpha/beta/alpha core. Proteins that contain domains with a thioredoxin-like fold include:Arsenate reductase (ArsC) []Calsequestrin (contains three tandem repeats of this fold) []Circadian oscillation regulator KaiB []Disulphide bond isomerase DsbC and DsbG (C-terminal domain) [, ]Disulphide bond facilitator DsbA (contains an alpha-helical insertion) []Endoplasmic reticulum protein ERP29 (N-terminal domain) []Glutathione S-transferase (GST) (N-terminal domain) []Mitochondrial ribosomal protein L51/S25/CI-B8 domain (variable positions for Cys residues in active site) []Phosducin []Protein disulphide isomerase (PDI) (contains two tandem repeats of this fold) []Glutathione peroxidase-like enzymes []Selenoprotein W-related []SH3-binding glutamic acid-rich protein like (SH3BGR) (lacks both conserved Cys residues) []Spliceosomal protein U5-15Kd []Thioltransferases, including thioredoxin [], glutaredoxon [], hybrid peroxiredoxin hyPrx5 []Thioredoxin-like 2Fe-2S ferredoxin [] Short Name:  Thioredoxin-like_fold

7 Child Features

DB identifier Type Name
IPR004045 Domain Glutathione S-transferase, N-terminal
IPR000866 Domain Alkyl hydroperoxide reductase subunit C/ Thiol specific antioxidant
IPR013766 Domain Thioredoxin domain
IPR013740 Domain Redoxin
IPR024253 Domain Phosducin, thioredoxin-like domain
IPR011649 Domain KaiB domain
IPR012941 Domain Phenol hydroxylase, C-terminal dimerisation domain

8 Contains

DB identifier Type Name
IPR019479 Domain Peroxiredoxin, C-terminal
IPR002109 Domain Glutaredoxin
IPR004879 Domain Domain of unknown function DUF255
IPR011767 Active_site Glutaredoxin active site
IPR017937 Conserved_site Thioredoxin, conserved site
IPR018219 Conserved_site Thiol peroxidase conserved site
IPR018233 Conserved_site Calsequestrin, conserved site
IPR008261 Active_site Iodothyronine deiodinase, active site

7 Cross Referencess


13 Found Ins

DB identifier Type Name
IPR009737 Family Sucraseferredoxin-like
IPR016639 Family Glutathione S-transferase (GST)
IPR014440 Family HCCA isomerase/glutathione S-transferase kappa
IPR012883 Domain ERp29, N-terminal
IPR017346 Family UBX domain-containing protein 2/7
IPR003083 Family S-crystallin
IPR014109 Family Type-F conjugative transfer system pilin assembly thiol-disulphide isomerase TrbB
IPR014111 Family Type IV conjugative transfer system protein TraF
IPR010296 Family Protein of unknown function DUF899, thioredoxin-like
IPR012863 Family Protein of unknown function DUF1636
IPR010350 Family Protein of unknown function DUF942, thioredoxin-like
IPR017167 Family Uncharacterised conserved protein UCP037291, glutaredoxin-related
IPR021170 Family DnaJ homologue subfamily C member 10

0 GO Annotation

0 Ontology Annotations

0 Parent Features

98904 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
430324 D8T917 PAC:15419273 Selaginella moellendorffii 572  
267328 D8RFS1 PAC:15410481 Selaginella moellendorffii 265  
410829 D8RG01 PAC:15408648 Selaginella moellendorffii 256  
440879 D8RF46 PAC:15407974 Selaginella moellendorffii 672  
67460 D8RFA1 PAC:15411521 Selaginella moellendorffii 235  
48885 D8TAJ9 PAC:15403029 Selaginella moellendorffii 117  
16302 D8RGX9 PAC:15416321 Selaginella moellendorffii 109  
15619 D8RGY4 PAC:15415751 Selaginella moellendorffii 164  
411345 D8RHC5 PAC:15407742 Selaginella moellendorffii 172  
411349 D8RHC9 PAC:15407745 Selaginella moellendorffii 166  
93274 D8RHC7 PAC:15419873 Selaginella moellendorffii 166  
93228 D8RHC8 PAC:15419768 Selaginella moellendorffii 132  
7911 D8RGY5 PAC:15405965 Selaginella moellendorffii 99  
93858 D8RGZ4 PAC:15402082 Selaginella moellendorffii 222  
93757 D8RHC4 PAC:15423558 Selaginella moellendorffii 178  
272288 D8TAV3 PAC:15402343 Selaginella moellendorffii 209  
135849 D8TAW2 PAC:15417238 Selaginella moellendorffii 183  
236794 D8TDP0 PAC:15411512 Selaginella moellendorffii 159  
96134 D8RKA7 PAC:15405395 Selaginella moellendorffii 104  
270941 D8RL44 PAC:15401788 Selaginella moellendorffii 226  
96390 D8RLB9 PAC:15407018 Selaginella moellendorffii 190  
97488 D8RMD6 PAC:15410851 Selaginella moellendorffii 193  
97421 D8RMF5 PAC:15410700 Selaginella moellendorffii 121  
187774 D8TF00 PAC:15413809 Selaginella moellendorffii 473  
141206 D8QUZ2 PAC:15407935 Selaginella moellendorffii 222  
165405 D8QUD2 PAC:15413425 Selaginella moellendorffii 254  
165383 D8QU96 PAC:15412788 Selaginella moellendorffii 221  
404313 D8QUY1 PAC:15409359 Selaginella moellendorffii 222  
404435 D8QVB5 PAC:15410201 Selaginella moellendorffii 311  
78425 D8QUA1 PAC:15421386 Selaginella moellendorffii 222  

20 Publications

First Author Title Year Journal Volume Pages PubMed ID