Protein Domain : IPR012336

Type:  Domain Name:  Thioredoxin-like fold
Description:  Several biological processes regulate the activity of target proteins through changes in the redox state of thiol groups (S2 to SH2), where a hydrogen donor is linked to an intermediary disulphide protein. Such processes include the ferredoxin/thioredoxin system, the NADP/thioredoxin system, and the glutathione/glutaredoxin system []. Several of these disulphide proteins share a common structure, consisting of a three-layer alpha/beta/alpha core. Proteins that contain domains with a thioredoxin-like fold include:Arsenate reductase (ArsC) []Calsequestrin (contains three tandem repeats of this fold) []Circadian oscillation regulator KaiB []Disulphide bond isomerase DsbC and DsbG (C-terminal domain) [, ]Disulphide bond facilitator DsbA (contains an alpha-helical insertion) []Endoplasmic reticulum protein ERP29 (N-terminal domain) []Glutathione S-transferase (GST) (N-terminal domain) []Mitochondrial ribosomal protein L51/S25/CI-B8 domain (variable positions for Cys residues in active site) []Phosducin []Protein disulphide isomerase (PDI) (contains two tandem repeats of this fold) []Glutathione peroxidase-like enzymes []Selenoprotein W-related []SH3-binding glutamic acid-rich protein like (SH3BGR) (lacks both conserved Cys residues) []Spliceosomal protein U5-15Kd []Thioltransferases, including thioredoxin [], glutaredoxon [], hybrid peroxiredoxin hyPrx5 []Thioredoxin-like 2Fe-2S ferredoxin [] Short Name:  Thioredoxin-like_fold
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7 Child Features

DB identifier Type Name
IPR004045 Domain Glutathione S-transferase, N-terminal
IPR000866 Domain Alkyl hydroperoxide reductase subunit C/ Thiol specific antioxidant
IPR013766 Domain Thioredoxin domain
IPR013740 Domain Redoxin
IPR024253 Domain Phosducin, thioredoxin-like domain
IPR011649 Domain KaiB domain
IPR012941 Domain Phenol hydroxylase, C-terminal dimerisation domain

8 Contains

DB identifier Type Name
IPR019479 Domain Peroxiredoxin, C-terminal
IPR002109 Domain Glutaredoxin
IPR004879 Domain Domain of unknown function DUF255
IPR011767 Active_site Glutaredoxin active site
IPR017937 Conserved_site Thioredoxin, conserved site
IPR018219 Conserved_site Thiol peroxidase conserved site
IPR018233 Conserved_site Calsequestrin, conserved site
IPR008261 Active_site Iodothyronine deiodinase, active site

7 Cross Referencess

Identifier
PF13098
PF13192
PF13462
PF13905
PS51352
G3DSA:3.40.30.10
SSF52833

13 Found Ins

DB identifier Type Name
IPR009737 Family Sucraseferredoxin-like
IPR016639 Family Glutathione S-transferase (GST)
IPR014440 Family HCCA isomerase/glutathione S-transferase kappa
IPR012883 Domain ERp29, N-terminal
IPR017346 Family UBX domain-containing protein 2/7
IPR003083 Family S-crystallin
IPR014109 Family Type-F conjugative transfer system pilin assembly thiol-disulphide isomerase TrbB
IPR014111 Family Type IV conjugative transfer system protein TraF
IPR010296 Family Protein of unknown function DUF899, thioredoxin-like
IPR012863 Family Protein of unknown function DUF1636
IPR010350 Family Protein of unknown function DUF942, thioredoxin-like
IPR017167 Family Uncharacterised conserved protein UCP037291, glutaredoxin-related
IPR021170 Family DnaJ homologue subfamily C member 10

0 GO Annotation

0 Ontology Annotations

0 Parent Features

97229 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
430324 D8T917 PAC:15419273 Selaginella moellendorffii 572  
267328 D8RFS1 PAC:15410481 Selaginella moellendorffii 265  
410829 D8RG01 PAC:15408648 Selaginella moellendorffii 256  
440879 D8RF46 PAC:15407974 Selaginella moellendorffii 672  
67460 D8RFA1 PAC:15411521 Selaginella moellendorffii 235  
48885 D8TAJ9 PAC:15403029 Selaginella moellendorffii 117  
16302 D8RGX9 PAC:15416321 Selaginella moellendorffii 109  
15619 D8RGY4 PAC:15415751 Selaginella moellendorffii 164  
411345 D8RHC5 PAC:15407742 Selaginella moellendorffii 172  
411349 D8RHC9 PAC:15407745 Selaginella moellendorffii 166  
93274 D8RHC7 PAC:15419873 Selaginella moellendorffii 166  
93228 D8RHC8 PAC:15419768 Selaginella moellendorffii 132  
7911 D8RGY5 PAC:15405965 Selaginella moellendorffii 99  
93858 D8RGZ4 PAC:15402082 Selaginella moellendorffii 222  
93757 D8RHC4 PAC:15423558 Selaginella moellendorffii 178  
272288 D8TAV3 PAC:15402343 Selaginella moellendorffii 209  
135849 D8TAW2 PAC:15417238 Selaginella moellendorffii 183  
236794 D8TDP0 PAC:15411512 Selaginella moellendorffii 159  
96134 D8RKA7 PAC:15405395 Selaginella moellendorffii 104  
270941 D8RL44 PAC:15401788 Selaginella moellendorffii 226  
96390 D8RLB9 PAC:15407018 Selaginella moellendorffii 190  
97488 D8RMD6 PAC:15410851 Selaginella moellendorffii 193  
97421 D8RMF5 PAC:15410700 Selaginella moellendorffii 121  
187774 D8TF00 PAC:15413809 Selaginella moellendorffii 473  
141206 D8QUZ2 PAC:15407935 Selaginella moellendorffii 222  
165405 D8QUD2 PAC:15413425 Selaginella moellendorffii 254  
165383 D8QU96 PAC:15412788 Selaginella moellendorffii 221  
404313 D8QUY1 PAC:15409359 Selaginella moellendorffii 222  
404435 D8QVB5 PAC:15410201 Selaginella moellendorffii 311  
78425 D8QUA1 PAC:15421386 Selaginella moellendorffii 222  

20 Publications

First Author Title Year Journal Volume Pages PubMed ID
            6852035
            11709171
            10700276
            15071498
            11435111
            10610776
            15862094
            9628486
            9300489
            1304339
            12089152
            12529327
            15341729
            15120624
            15184683
            10383197
            8898209
            2181145
            16319061
            16597834