| Type: | Domain | Name: | ACT-like domain |
| Description: | The ACT domain is a 90 amino acid long domain, which has been named after three of the allosterically regulated enzymes in which it is found: aspartate kinase, chorismate mutase and TyrA (prephenate dehydrogenase) []. The ACT domain is found in a variety of contexts and is proposed to be a structurally conserved regulatory domain involved in the binding of small ligands, such as amino acids. Most of the proteins in which it is found are involved in amino acid and purine metabolism:aspartokinaseschorismate mutasesprephenate dehydrogenases (TyrA)prephenate dehydrataseshomoserine dehydrogenasesmalate dehydrogenasesphosphoglycerate dehydrogenasesphenylalanine and tryptophan-4-monooxygenasesphosphoribosylformylglycinamidine synthase (PurQ)uridylyl transferase and removing enzyme (GlnD)GTP pyrophosphokinase/phosphohydrolase (SpoT/RelA)tyrosine and phenol metabolism operon regulators (TyrR)several uncharacterised proteins from archaea, bacteria and plants that contain from one to four copies of this domain []. | Short Name: | ACT-like_dom |
