Protein Domain : IPR011989

Type:  Domain Name:  Armadillo-like helical
Description:  This domain consists of a multi-helical fold comprised of two curved layers of alpha helices arranged in a regular right-handed superhelix, where the repeats that make up this structure are arranged about a common axis []. These superhelical structures present an extensive solvent-accessible surface that is well suited to binding large substrates such as proteins and nucleic acids. This topology has been found with a number of repeats and domains, including the armadillo repeat (found in beta-catenins and importins), the HEAT repeat (found in protein phosphatase 2a and initiation factor eIF4G), the PHAT domain (found in Smaug RNA-binding protein), the leucine-rich repeat variant, the Pumilo repeat, and in the H regulatory subunit of V-type ATPases. The sequence similarity among these different repeats or domains is low, however they exhibit considerable structural similarity. Furthermore, the number of repeats present in the superhelical structure can vary between orthologues, indicating that rapid loss/gain of repeats has occurred frequently in evolution. A common phylogenetic origin has been proposed for the armadillo and HEAT repeats []. Short Name:  ARM-like
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2 Child Features

DB identifier Type Name
IPR002553 Domain Clathrin/coatomer adaptor, adaptin-like, N-terminal
IPR024574 Domain Domain of unknown function DUF3361

16 Contains

DB identifier Type Name
IPR014877 Domain CRM1 C-terminal domain
IPR007205 Domain Protein HGH1 N-terminal
IPR004155 Repeat PBS lyase HEAT-like repeat
IPR013918 Domain Nucleotide exchange factor Fes1
IPR021133 Repeat HEAT, type 2
IPR000225 Repeat Armadillo
IPR001313 Repeat Pumilio RNA-binding repeat
IPR001494 Domain Importin-beta, N-terminal domain
IPR013713 Domain Exportin/Importin, Cse1-like
IPR005043 Domain CAS/CSE, C-terminal
IPR013932 Domain TATA-binding protein interacting (TIP20)
IPR013598 Domain Exportin-1/Importin-beta-like
IPR000357 Repeat HEAT repeat
IPR002015 Repeat Proteasome/cyclosome repeat
IPR007206 Domain Protein HGH1 C-terminal
IPR004830 Repeat Leucine rich repeat variant

1 Cross References

Identifier
G3DSA:1.25.10.10

15 Found Ins

DB identifier Type Name
IPR017104 Family Adaptor protein complex AP-2, alpha subunit
IPR017106 Family Coatomer gamma subunit
IPR016642 Family 26S proteasome regulatory complex, non-ATPase subcomplex, Rpn2/Psmd1 subunit
IPR008658 Family Kinesin-associated protein 3
IPR016460 Family Coatomer beta subunit (COPB1)
IPR016342 Family AP-1, 2,4 complex subunit beta
IPR017109 Family Adaptor protein complex AP-4, epsilon subunit
IPR004908 Family ATPase, V1 complex, subunit H
IPR017105 Family Adaptor protein complex AP-3, delta subunit
IPR017107 Family Adaptor protein complex AP-1, gamma subunit
IPR006911 Domain Armadillo repeat-containing domain
IPR007673 Family Condensin subunit 1
IPR013284 Family Beta-catenin
IPR008665 Domain LRV FeS4 cluster
IPR011959 Family Conserved hypothetical protein CHP02270

0 GO Annotation

0 Ontology Annotations

1 Parent Features

DB identifier Type Name
IPR016024 Domain Armadillo-type fold

123213 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
146848 D8RG19 PAC:15404934 Selaginella moellendorffii 484  
410663 D8RFG5 PAC:15407140 Selaginella moellendorffii 740  
410765 D8RFT0 PAC:15407915 Selaginella moellendorffii 803  
440913 D8RFB7 PAC:15408656 Selaginella moellendorffii 1701  
441002 D8RFY3 PAC:15404615 Selaginella moellendorffii 623  
73073 D8RFV3 PAC:15403819 Selaginella moellendorffii 101  
236562 D8TAL0 PAC:15409872 Selaginella moellendorffii 1688  
61948 D8RHP8 PAC:15420046 Selaginella moellendorffii 352  
162778 D8TBU8 PAC:15406947 Selaginella moellendorffii 1469  
411667 D8RIN0 PAC:15410234 Selaginella moellendorffii 785  
172230 D8RKK7 PAC:15410363 Selaginella moellendorffii 408  
412413 D8RL27 PAC:15411503 Selaginella moellendorffii 922  
412624 D8RM36 PAC:15413071 Selaginella moellendorffii 1556  
432055 PAC:15422795 Selaginella moellendorffii 305  
172660 D8RMD2 PAC:15413499 Selaginella moellendorffii 723  
97336 D8RMG5 PAC:15409918 Selaginella moellendorffii 1256  
1983 D8QV41 PAC:15411026 Selaginella moellendorffii 337  
165698 D8QW17 PAC:15415126 Selaginella moellendorffii 866  
230150 D8QVZ4 PAC:15411601 Selaginella moellendorffii 445  
230130 D8QV86 PAC:15411562 Selaginella moellendorffii 1156  
404013 D8QU03 PAC:15406958 Selaginella moellendorffii 1173  
404572 D8QVR9 PAC:15411100 Selaginella moellendorffii 1455  
404660 D8QW06 PAC:15411803 Selaginella moellendorffii 1715  
78052 D8QUB8 PAC:15418509 Selaginella moellendorffii 340  
78497 D8QU44 PAC:15421560 Selaginella moellendorffii 353  
78585 D8QUV8 PAC:15422327 Selaginella moellendorffii 340  
78845 D8QW92 PAC:15402274 Selaginella moellendorffii 1247  
148739 D8RNY3 PAC:15410117 Selaginella moellendorffii 804  
228162 D8RPE1 PAC:15405379 Selaginella moellendorffii 887  
413208 D8RNP6 PAC:15412850 Selaginella moellendorffii 817  

2 Publications

First Author Title Year Journal Volume Pages PubMed ID
            10361086
            11551174