Protein Domain : IPR013786

Type:  Domain Name:  Acyl-CoA dehydrogenase/oxidase, N-terminal
Description:  Acyl-CoA dehydrogenases () are a family of flavoproteins that catalyse the alpha,beta-dehydrogenation of acyl-CoA thioesters to the corresponding trans 2,3-enoyl CoA-products with the concomitant reduction of enzyme-bound FAD. Different family members share a high sequence identity, catalytic mechanisms, and structural properties, but differ in the position of their catalytic bases and in their substrate binding specificity. Butyryl-CoA dehydrogenase [] prefers short chain substrates, medium chain- and long-chain acyl-CoA dehydrogenases prefer medium and long chain substrates, respectively, and Isovaleryl-CoA dehydrogenase [] prefers branched-chain substrates.The monomeric enzyme is folded into three domains of approximately equal size, where the N-terminal domain is all-alpha, the middle domain is an open (5,8) barrel, and the C-terminal domain is a four-helical bundle. The constituent families differ in the numbers of C-terminal domains. This entry represents the N-terminal alpha-helical domain found in medium chain acyl-CoA dehydrogenases, as well as in the related peroxisomal acyl-CoA oxidase-II enzymes. Acyl-CoA oxidase (ACO; ) catalyzes the first and rate-determining step of the peroxisomal beta-oxidation of fatty acids []. Short Name:  AcylCoA_DH/ox_N

1 Child Features

DB identifier Type Name
IPR029320 Domain Acyl-coenzyme A oxidase, N-terminal

0 Contains

2 Cross Referencess

Identifier
PF02771
G3DSA:1.10.540.10

0 Found In

4 GO Annotations

GO Term Gene Name
GO:0016627 IPR013786
GO:0050660 IPR013786
GO:0008152 IPR013786
GO:0055114 IPR013786

4 Ontology Annotations

GO Term Gene Name
GO:0016627 IPR013786
GO:0050660 IPR013786
GO:0008152 IPR013786
GO:0055114 IPR013786

0 Parent Features

3256 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
443456 D8S1M7 PAC:15413848 Selaginella moellendorffii 1081  
233033 D8S3D8 PAC:15419513 Selaginella moellendorffii 788  
444204 D8S7U7 PAC:15415076 Selaginella moellendorffii 811  
164182 D8QMY6 PAC:15408229 Selaginella moellendorffii 429  
428295 D8T2D4 PAC:15412577 Selaginella moellendorffii 393  
90623 D8RCV7 PAC:15414145 Selaginella moellendorffii 415  
evm.model.supercontig_106.30 PAC:16405194 Carica papaya 201  
evm.model.supercontig_11.100 PAC:16405586 Carica papaya 435  
evm.model.supercontig_139.79 PAC:16408581 Carica papaya 408  
evm.model.supercontig_50.161 PAC:16421623 Carica papaya 827  
29726.m004084 B9RT92 PAC:16806794 Ricinus communis 822  
29726.m004085 B9RT93 PAC:16806795 Ricinus communis 830  
30111.m000733 B9SK49 PAC:16817890 Ricinus communis 406  
31799.m000015 B9TIH3 PAC:16825192 Ricinus communis 355  
32605.m000032 B9TG78 PAC:16825492 Ricinus communis 135  
34804.m000034 B9TI84 PAC:16826355 Ricinus communis 85  
35174.m000020 B9TDF4 PAC:16826506 Ricinus communis 367  
35800.m000029 B9TCW2 PAC:16826731 Ricinus communis 404  
47455.m000025 B9TQ38 PAC:16827998 Ricinus communis 102  
28176.m000270 B9T1J4 PAC:16800206 Ricinus communis 440  
Cucsa.084510.1 PAC:16956547 Cucumis sativus 262  
Cucsa.141830.1 A0A0A0LZ29 PAC:16963536 Cucumis sativus 639  
Cucsa.176490.1 A0A0A0LCR8 PAC:16966898 Cucumis sativus 440  
Cucsa.252870.1 A0A0A0L5U9 PAC:16971998 Cucumis sativus 830  
Cucsa.252870.2 A0A0A0L5U9 PAC:16971999 Cucumis sativus 830  
Cucsa.252870.3 PAC:16972000 Cucumis sativus 740  
orange1.1g021093m A0A067DD15 PAC:18139804 Citrus sinensis 317  
orange1.1g020876m A0A067DE44 PAC:18139803 Citrus sinensis 320  
orange1.1g037169m PAC:18107594 Citrus sinensis 860  
orange1.1g045528m A0A067FI10 PAC:18111515 Citrus sinensis 195  

3 Publications

First Author Title Year Journal Volume Pages PubMed ID
            11872165
            11812788
            9214289