3 Ontology Annotations
| GO Term | Gene Name |
|---|---|
| GO:0016627 | IPR009100 |
| GO:0008152 | IPR009100 |
| GO:0055114 | IPR009100 |
| Type: | Domain | Name: | Acyl-CoA dehydrogenase/oxidase, N-terminal and middle domain |
| Description: | Acyl-CoA dehydrogenases () are a family of flavoproteins that catalyse the alpha,beta-dehydrogenation of acyl-CoA thioesters to the corresponding trans 2,3-enoyl CoA-products with the concomitant reduction of enzyme-bound FAD. Different family members share a high sequence identity, catalytic mechanisms, and structural properties, but differ in the position of their catalytic bases and in their substrate binding specificity. Butyryl-CoA dehydrogenase [] prefers short chain substrates, medium chain- and long-chain acyl-CoA dehydrogenases prefer medium and long chain substrates, respectively, and Isovaleryl-CoA dehydrogenase [] prefers branched-chain substrates.The monomeric enzyme is folded into three domains of approximately equal size, where the N-terminal domain is all-alpha, the middle domain is an open (5,8) barrel, and the C-terminal domain is a four-helical bundle. The constituent families differ in the numbers of C-terminal domains. This entry represents both the N-terminal and middle domains found in medium chain acyl-CoA dehydrogenases, as well as in the related peroxisomal acyl-CoA oxidase-II enzymes. Acyl-CoA oxidase (ACO; ) catalyzes the first and rate-determining step of the peroxisomal beta-oxidation of fatty acids []. | Short Name: | AcylCoA_DH/oxidase_NM_dom |
| GO Term | Gene Name |
|---|---|
| GO:0016627 | IPR009100 |
| GO:0008152 | IPR009100 |
| GO:0055114 | IPR009100 |
