1 Found In
DB identifier | Type | Name |
---|---|---|
IPR006515 | Family | Polyadenylate binding protein, human types 1, 2, 3, 4 |
Type: | Domain | Name: | Polyadenylate-binding protein/Hyperplastic disc protein |
Description: | The polyadenylate-binding protein (PABP) has a conserved C-terminal domain (PABC), which is also found in the hyperplastic discs protein (HYD) family of ubiquitin ligases that contain HECT domains () []. PABP recognises the 3' mRNA poly(A) tail and plays an essential role in eukaryotic translation initiation and mRNA stabilisation/degradation. PABC domains of PABP are peptide-binding domains that mediate PABP homo-oligomerisation and protein-protein interactions. In mammals, the PABC domain of PABP functions to recruit several different translation factors to the mRNA poly(A) tail []. | Short Name: | PABP_HYD |
DB identifier | Type | Name |
---|---|---|
IPR006515 | Family | Polyadenylate binding protein, human types 1, 2, 3, 4 |