Protein Domain : IPR001251

Type:  Domain Name:  CRAL-TRIO lipid binding domain
Description:  The CRAL-TRIO domain is a protein structural domain that binds small lipophilic molecules []. The domain is named after cellular retinaldehyde-binding protein (CRALBP) and TRIO guanine exchange factor.The CRAL-TRIO domain is found in GTPase-activating proteins (GAPs), guanine nucleotide exchange factors (GEFs) and a family of hydrophobic ligand binding proteins, including the yeast SEC14 protein and mammalian retinaldehyde- and alpha-tocopherol-binding proteins. The domain may either constitute all of the protein or only part of it [, , , ].The structure of the domain in SEC14 proteins has been determined []. The structure contains several alpha helices as well as a beta sheet composed of 6 strands. Strands 2,3,4 and 5 form a parallel beta sheet with strands 1 and 6 being anti-parallel. The structure also identified a hydrophobic binding pocket for lipid binding. Short Name:  CRAL-TRIO_dom
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0 Child Features

0 Contains

6 Cross Referencess

Identifier
PF00650
PF13716
PS50191
SM00516
G3DSA:3.40.525.10
SSF52087

1 Found In

DB identifier Type Name
IPR001071 Family Cellular retinaldehyde binding/alpha-tocopherol transport

0 GO Annotation

0 Ontology Annotations

0 Parent Features

3256 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
65145 D8RF42 PAC:15403205 Selaginella moellendorffii 348  
92905 D8RF01 PAC:15422013 Selaginella moellendorffii 273  
93038 D8RF39 PAC:15418263 Selaginella moellendorffii 363  
412840 D8RMH4 PAC:15414703 Selaginella moellendorffii 253  
11806 D8RV67 PAC:15405461 Selaginella moellendorffii 290  
418109 D8S4Q0 PAC:15404258 Selaginella moellendorffii 348  
111930 D8S9X5 PAC:15414283 Selaginella moellendorffii 292  
114753 D8SE09 PAC:15421377 Selaginella moellendorffii 260  
271658 D8SK62 PAC:15402400 Selaginella moellendorffii 355  
121430 D8SNU1 PAC:15417596 Selaginella moellendorffii 221  
43741 D8SQF2 PAC:15409981 Selaginella moellendorffii 418  
168470 D8R540 PAC:15422160 Selaginella moellendorffii 227  
439610 D8R6F4 PAC:15403121 Selaginella moellendorffii 427  
22919 D8QPC3 PAC:15416406 Selaginella moellendorffii 252  
89782 D8RBK6 PAC:15411790 Selaginella moellendorffii 194  
77842 D8QR90 PAC:15421575 Selaginella moellendorffii 308  
90159 D8RCE9 PAC:15410335 Selaginella moellendorffii 339  
91055 D8RDF5 PAC:15412489 Selaginella moellendorffii 566  
91570 D8RE23 PAC:15416323 Selaginella moellendorffii 601  
evm.TU.contig_24748.6 PAC:16429371 Carica papaya 354  
evm.TU.contig_27553.2 PAC:16429504 Carica papaya 223  
evm.TU.contig_29302.2 PAC:16429684 Carica papaya 115  
evm.TU.contig_37837.1 PAC:16431084 Carica papaya 383  
evm.TU.contig_39307.1 PAC:16431319 Carica papaya 393  
evm.model.supercontig_1.88 PAC:16404435 Carica papaya 552  
evm.model.supercontig_106.10 PAC:16405151 Carica papaya 585  
evm.model.supercontig_106.9 PAC:16405259 Carica papaya 518  
evm.model.supercontig_12.124 PAC:16406664 Carica papaya 336  
evm.model.supercontig_12.74 PAC:16406916 Carica papaya 619  
evm.model.supercontig_138.20 PAC:16408454 Carica papaya 562  

5 Publications

First Author Title Year Journal Volume Pages PubMed ID
            8349655
            9461221
            2198263
            10829015
            12767229