Protein Domain : IPR002652

Type:  Domain Name:  Importin-alpha, importin-beta-binding domain
Description:  The exchange of macromolecules between the nucleus and cytoplasm takes place through nuclear pore complexes within the nuclear membrane. Active transport of large molecules through these pore complexes require carrier proteins, called karyopherins (importins and exportins), which shuttle between the two compartments.Members of the importin-alpha (karyopherin-alpha) family can form heterodimers with importin-beta. As part of a heterodimer, importin-beta mediates interactions with the pore complex, while importin-alpha acts as an adaptor protein to bind the nuclear localisation signal (NLS) on the cargo through the classical NLS import of proteins. Proteins can contain one (monopartite) or two (bipartite) NLS motifs. Importin-alpha contains several armadillo (ARM) repeats, which produce a curving structure with two NLS-binding sites, a major one close to the N terminus and a minor one close to the C terminus.Ran GTPase helps to control the unidirectional transfer of cargo. The cytoplasm contains primarily RanGDP and the nucleus RanGTP through the actions of RanGAP and RanGEF, respectively. In the nucleus, RanGTP binds to importin-beta within the importin/cargo complex, causing a conformational change in importin-beta that releases it from importin-alpha-bound cargo. The N-terminal importin-beta-binding (IBB) domain of importin-alpha contains an auto-regulatory region that mimics the NLS motif []. The release of importin-beta frees the auto-regulatory region on importin-alpha to loop back and bind to the major NLS-binding site, causing the cargo to be released [].This entry represents the N-terminal IBB domain of importin-alpha that contains the auto-regulatory region. Short Name:  Importin-a_IBB
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0 Child Features

0 Contains

3 Cross Referencess

Identifier
PF01749
PS51214
G3DSA:1.20.5.690

1 Found In

DB identifier Type Name
IPR017336 Family Snurportin-1

4 GO Annotations

GO Term Gene Name
GO:0008565 IPR002652
GO:0006606 IPR002652
GO:0005634 IPR002652
GO:0005737 IPR002652

4 Ontology Annotations

GO Term Gene Name
GO:0008565 IPR002652
GO:0006606 IPR002652
GO:0005634 IPR002652
GO:0005737 IPR002652

0 Parent Features

3256 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
417518 D8S2H7 PAC:15404414 Selaginella moellendorffii 367  
266556 D8QMK6 PAC:15409102 Selaginella moellendorffii 527  
evm.model.supercontig_151.53 PAC:16409573 Carica papaya 518  
evm.model.supercontig_48.134 PAC:16420767 Carica papaya 542  
evm.model.supercontig_48.177 PAC:16420814 Carica papaya 536  
evm.model.supercontig_9.100 PAC:16427981 Carica papaya 530  
29889.m003249 B9RZK9 PAC:16812196 Ricinus communis 488  
30076.m004698 B9RNI4 PAC:16817307 Ricinus communis 78  
30128.m008927 B9RFK9 PAC:16818513 Ricinus communis 450  
30128.m008884 B9RFG6 PAC:16818470 Ricinus communis 531  
Cucsa.090870.1 PAC:16957372 Cucumis sativus 529  
Cucsa.090870.2 PAC:16957373 Cucumis sativus 529  
Cucsa.090870.3 PAC:16957374 Cucumis sativus 524  
Cucsa.090870.5 PAC:16957376 Cucumis sativus 415  
Cucsa.090870.6 PAC:16957377 Cucumis sativus 381  
Cucsa.090540.1 A0A0A0LM44 PAC:16957307 Cucumis sativus 537  
Cucsa.069450.2 PAC:16955453 Cucumis sativus 373  
Cucsa.069450.1 A0A0A0KCZ8 PAC:16955452 Cucumis sativus 530  
orange1.1g032746m A0A067D995 PAC:18129059 Citrus sinensis 134  
orange1.1g016714m A0A067H1Q7 PAC:18107804 Citrus sinensis 384  
orange1.1g009184m A0A067H2G5 PAC:18108293 Citrus sinensis 541  
orange1.1g009622m A0A067GST9 PAC:18108294 Citrus sinensis 530  
orange1.1g009623m A0A067GST9 PAC:18108295 Citrus sinensis 530  
orange1.1g009636m A0A067GST9 PAC:18108296 Citrus sinensis 530  
orange1.1g009627m A0A067GST9 PAC:18108297 Citrus sinensis 530  
orange1.1g014864m A0A067H2G8 PAC:18108298 Citrus sinensis 417  
orange1.1g015537m A0A067H228 PAC:18108299 Citrus sinensis 405  
orange1.1g009700m A0A067G0R5 PAC:18109391 Citrus sinensis 528  
orange1.1g017651m A0A067G8V5 PAC:18109880 Citrus sinensis 368  
orange1.1g017638m A0A067G8V5 PAC:18109881 Citrus sinensis 368  

2 Publications

First Author Title Year Journal Volume Pages PubMed ID
            17170104
            8692858