| Type: | Family | Name: | NADH-ubiquinone oxidoreductase, 20 Kd subunit |
| Description: | NADH:ubiquinone oxidoreductase (complex I) () is a respiratory-chain enzyme that catalyses the transfer of two electrons from NADH to ubiquinone in a reaction that is associated with proton translocation across the membrane (NADH + ubiquinone = NAD+ + ubiquinol) []. Complex I is a major source of reactive oxygen species (ROS) that are predominantly formed by electron transfer from FMNH(2). Complex I is found in bacteria, cyanobacteria (as a NADH-plastoquinone oxidoreductase), archaea [], mitochondria, and in the hydrogenosome, a mitochondria-derived organelle. In general, the bacterial complex consists of 14 different subunits, while the mitochondrial complex contains homologues to these subunits in addition to approximately 31 additional proteins []. Among the many polypeptide subunits that make up complex I, there is one with a molecular weight of 20 kDa (in mammals) [], which is a component of the iron-sulphur (IP) fragment of the enzyme. It seems to bind a 4Fe-4S iron-sulphur cluster. The 20 kDa subunit has been found to be nuclear encoded, as a precursor form with a transit peptide in mammals, and in Neurospora crassa. It is mitochondrial encoded in Paramecium (gene psbG) and chloroplast encoded in various higher plants (gene ndhK or psbG). | Short Name: | NADH_UQ_OxRdtase_20Kd_su |
| DB identifier | Type | Name |
|---|---|---|
| IPR006137 | Domain | NADH:ubiquinone oxidoreductase-like, 20kDa subunit |
| GO Term | Gene Name |
|---|---|
| GO:0008137 | IPR006138 |
| GO:0048038 | IPR006138 |
| GO:0051539 | IPR006138 |
| GO:0055114 | IPR006138 |
| GO Term | Gene Name |
|---|---|
| GO:0008137 | IPR006138 |
| GO:0048038 | IPR006138 |
| GO:0051539 | IPR006138 |
| GO:0055114 | IPR006138 |
